中国医疗设备2025，Vol.40Issue(2)：6-12,23,8.DOI:10.3969/j.issn.1674-1633.20241038
基于近红外漫射光谱的多通道乳腺组织血氧监测系统及其校准方法
Multi-Channel Breast Tissue Blood Oxygen Saturation Monitoring System and Calibration Approach Based on Near-Infrared Diffuse Optical Spectroscopy
摘要
Abstract
Objective To design a breast blood oxygen monitoring system and explore calibration algorithms to ensure accurate reflection of breast tissue blood oxygen saturation.Methods A four-channel breast blood oxygen monitoring system with three wavelengths(660,805 and 904 nm)was designed based on near-infrared diffuse optical spectroscopy technology.A solid-state phantom with human tissue-mimic absorption and scattering properties was fabricated as a calibration tool,and the calibration algorithms were designed.According to the light intensity values of the far and near ends of each channel light source and detector,the standard values obtained by experiments were used as reference,and the light intensity parameters of each channel were adjusted to achieve the calibration of the oximeter.Results The experimental results showed that the absorption coefficient of solid phantom had a good linear relationship with the light intensity values of different channels(R2>0.98,P<0.001).Bland-Altman analysis showed that the difference between the calibrated lab-made and commercial oximeters at most measurement points fell within the 95%agreement limit with no significant system bias.Conclusion The system and calibration algorithm developed in this study are necessary steps for the early monitoring of breast diseases with near-infrared diffuse optical spectroscopy.The experimental results show that this method improves the accuracy of blood oxygen measurement,and provides a reference for medical diagnosis and treatment.关键词
近红外/漫射光谱/组织血氧饱和度/多通道/无创/仿体/校准Key words
near-infrared/diffuse optical spectroscopy/tissue blood oxygen saturation/multi-channel/non-invasive/phantom/calibrate分类
医药卫生引用本文复制引用
孙王玮,徐舒宁,王珺琪,吴旭升,桂志国,尚禹..基于近红外漫射光谱的多通道乳腺组织血氧监测系统及其校准方法[J].中国医疗设备,2025,40(2):6-12,23,8.基金项目
国家重点研发计划(2023YFE0202800) （2023YFE0202800）
山西省基础研究计划项目(202203021221097 （）
202203021211100) （）
中北大学研究生科技立项(20231932 （）
220221831 （）
20221833 （）
2022180502). （）
