云南民族大学学报（自然科学版）2025，Vol.34Issue(1)：61-67,76,8.DOI:10.3969/j.issn.1672-8513.2025.01.008
肠道内环境稳态对高尿酸血症及尿酸性肾病调控的研究进展
Research progress on the regulation of intestinal homeostasis on hyperuricemia and uric acid nephropathy
摘要
Abstract
In recent years,with the continuous improvement of the economic level of Chinese residents,the inci-dence of hyperuricemia has increased year by year,and the patients gradually tend to become younger.Long-term high serum uric acid not only greatly increases the risk of gout attack,but also leads to the occurrence of dis-eases such as uric acid nephropathy,which brings great burden to people's normal life and physical health.Most of the excretion of uric acid in the body is completed through the kidney,and a small part is excreted by the intes-tine.With the maturity of the intestinal ecosystem theory and the emergence of intestinal engineering bacteria,the intestinal ecosystem is also known as the"barometer"of human health.The mutual regulation effect of human intestinal environmental homeostasis and human uric acid metabolism has also gradually become clear.Therefore,this paper reviews the bidirectional channel effect of intestinal flora on hyperuricemia and uric acid nephropathy,and provides a new reference for the prevention and treatment of hyperuricemia and uric acid nephropathy.关键词
高尿酸血症/尿酸性肾病/肠道菌群/痛风Key words
hyperuricemia/uric acid kidney disease/intestinal flora/gout分类
医药卫生引用本文复制引用
张绍时,王明月,安孟飞,盛军,王宣军..肠道内环境稳态对高尿酸血症及尿酸性肾病调控的研究进展[J].云南民族大学学报（自然科学版）,2025,34(1):61-67,76,8.基金项目
云南省科技厅基金项目(202001AZ070001-062 （）
2018IA060 （）
2018FG001-035 （）
2019ZG00904 （）
2019ZG00909). （）
