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Paris saponin Ⅶ induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling

Xiaoying Qian Yang Liu Wenwen Chen Shuxian Zheng Yunyang Lu Pengcheng Qiu Xisong Ke Haifeng Tang Xue Zhang

中草药（英文版）2025，Vol.17Issue(1)：94-107,14.

中草药（英文版）2025，Vol.17Issue(1)：94-107,14.DOI:10.1016/j.chmed.2024.04.004

Paris saponin Ⅶ induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling

Xiaoying Qian ¹Yang Liu ²Wenwen Chen ²Shuxian Zheng ³Yunyang Lu ²Pengcheng Qiu ²Xisong Ke ⁴Haifeng Tang ²Xue Zhang⁴

作者信息

1. Center for Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China||Department of Chinese Materia Medico and Natural Medicines,School of Pharmacy,Air Force Medical University,Xi'an 710032,China
2. Department of Chinese Materia Medico and Natural Medicines,School of Pharmacy,Air Force Medical University,Xi'an 710032,China
3. School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China
4. Center for Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
折叠

摘要

关键词

Caspase-3/gasdermin E/pancreatic ductal adenocarcinoma/paris saponin Ⅶ/pyroptosis/reactive oxygen species

Key words

Caspase-3/gasdermin E/pancreatic ductal adenocarcinoma/paris saponin Ⅶ/pyroptosis/reactive oxygen species

引用本文复制引用

Xiaoying Qian,Yang Liu,Wenwen Chen,Shuxian Zheng,Yunyang Lu,Pengcheng Qiu,Xisong Ke,Haifeng Tang,Xue Zhang..Paris saponin Ⅶ induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling[J].中草药（英文版）,2025,17(1):94-107,14.

基金项目

This work was supported by the National Natural Science Foun-dation of China(No.81973192). （No.81973192）

中草药（英文版）

ISSN：1674-6384

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