中国临床药学杂志2024，Vol.33Issue(12)：923-928,6.DOI:10.19577/j.1007-4406.2024.12.008
重组人生长激素联合曲普瑞林对特发性中枢性早熟女童卵巢功能及骨代谢指标的影响
Impacts of recombinant human growth hormone combined with triptorelin on ovarian function and levels of bone metabolism indicators in girls with idiopathic central precocious puberty
摘要
Abstract
AIM To investigate the impacts of recombinant human growth hormone combined with triptorelin on ovarian function and levels of bone metabolism indicators[N-terminal middle osteocalcin(N-MID),procollagen type ⅠN-terminal peptide(PINP),β-isomerized carboxy-terminal telopeptides collagen type Ⅰ(β-CTX)]in girls with idiopathic central precocious puberty.METHODS Using a prospective study approach,80 girls with idiopathic central precocious puberty admitted to Zunhua People's Hospital from February 2021 to March 2022 were selected as the research subjects.A randomized numerical table method was used to divide them into the conventional group(40 patients,treated with triptorelin)and the combination group(40 patients,treated with recombinant human growth hormone and triptorelin).After 48 weeks of treatment,the 2 groups were compared regarding predicted adult height,bone age difference/chronological age difference(△BA/△CA),annual average growth velocity(△GV),bone metabolism indicators(N-MID,PINP,β-CTX),ovarian function[ovarian and uterine volume,luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E2)levels],and clinical efficacy.RESULTS After treatment,the predicted adult height and △GV in the combined group were higher than those in the conventional group.At the same time,△BA/△CA was lower than that in the conventional group,and the difference was highly statistically significant(P＜0.01).The level of β-CTX in the combined group was higher than that in the conventional group,while the levels of N-MID and PINP were lower than those in the conventional group,and the differences were highly statistically significant(P＜0.01).The ovarian volume,uterine volume and levels of LH,FSH and E2 in the combined group were lower than those in the conventional group,and the differences were highly statistically significant(P＜0.01).The total effective rate of treatment in the combined group was higher than that in the conventional group,and the difference was statistically significant(92.50％vs 75.00％,P＜0.05).There was no significant difference in the total incidence of adverse reactions between the 2 groups(27.50％vs 15.00％,P＞0.05).CONCLUSION Recombinant human growth hormone combined with triptorelin can reduce N-MID levels in girls with idiopathic central precocious puberty,delay ovarian development,and has shown an obvious therapeutic effect.关键词
重组人生长激素/曲普瑞林/特发性中枢性早熟女童/卵巢功能/骨钙素N端中分子片段Key words
recombinant human growth hormone/triptorelin/girls with idiopathic central precocious puberty/ovarian function/N-terminal middle osteocalcin引用本文复制引用
杨淑雁,高丽艳,秦晓丰,张玉伶,王术梅,王静..重组人生长激素联合曲普瑞林对特发性中枢性早熟女童卵巢功能及骨代谢指标的影响[J].中国临床药学杂志,2024,33(12):923-928,6.基金项目
河北医学科学研究课题计划项目(编号20231876) （编号20231876）
