中国临床药学杂志2024，Vol.33Issue(12)：929-934,6.DOI:10.19577/j.1007-4406.2024.12.009
艾迪注射液与5％葡萄糖注射液或0.9％氯化钠注射液的配伍稳定性
Investigation on the compatibility stability of Aidi injection with 5％glucose injection or 0.9％sodium chloride injection
摘要
Abstract
AIM To investigate the compatible stability of Aidi injection with 5％glucose injection(5％GS)or 0.9％sodium chloride injection(0.9％NS)at different storage times and temperatures,to provide reference for clinical safety and rational use of the Aidi injection.METHODS According to the instructions,compatibility solutions of Aidi injection with 0.9％NS or 5％GS were to be prepared to simulate the clinical application,named the NS compatibility solution and the GS compatibility solution,respectively.Changes in appearance,pH value,insoluble particles,and the content of ginsenoside Rg1,ginsenoside Rbi,and syringin in 2 compatibility solutions were investigated under different storage times(0,1,2,4,8,12,24 h)and temperatures(25,35,45℃).RESULTS No significant changes in appearance were observed for either the NS compatibility solution or the GS compatibility solution within 24 hours,and the pH value fluctuated within the range tolerable by the human body(4-9).There was no significant difference in the number of insoluble particles with a particle size of ≥ 10 μm by the placement time,while the temperature exhibited a certain effect on the number of insoluble particles.The degradation rate of 3 components in 0.9％NS was lower than that in 5％GS.CONCLUSION In preparing Aidi injection,it is recommended to mix with 0.9％NS preferentially,the mixed medicine should be infused within 1-2 hours at a temperature below 25℃.关键词
艾迪注射液/配伍稳定性/含量测定/成品输液Key words
Aidi injection/compatibility stability/content determination/infusion引用本文复制引用
张生潭,武红娜,段利瑶,宝志,李彦儒,姚超然,姚晨..艾迪注射液与5％葡萄糖注射液或0.9％氯化钠注射液的配伍稳定性[J].中国临床药学杂志,2024,33(12):929-934,6.基金项目
河北省中医药管理局指令性科研课题(编号2023245) （编号2023245）
河北省卫生健康委员会医学科研课题(编号20220688) （编号20220688）
