中国兽医科学2025，Vol.55Issue(2)：272-278,7.DOI:10.16656/j.issn.1673-4696.2025.0017
附子理中口服液对雏鸡生长性能和肾功能的影响
Effects of Fuzi Lizhong oral liquid on growth performance and kidney function of chicks
摘要
Abstract
To investigate the effects of Fuzi Lizhong oral liquid on growth performance and kidney function of chicks,200 1-day-old healthy chicks were randomly divided into 5 groups.The control group(CG group)was given normal tap water.Flufenicol group(FF group)was given tap water containing 0.15 g/L flufenicol.The high,medium and low dose groups(FZH group,FZM group and FZL group)were given tap water containing 5 g/L,2.5 g/L and 1.25 g/L of Fuzi Lizhong oral liquid,respectively.Starting from the first day of age,the drug was administered continuously for 5 days,and the blood was collected from the sub-wing vein on the sixth day of the test.The results showed that compared with CG group,ADFI and ADG in FZH group were significantly increased(P＜0.05),and F/G in FZL,FZM and FZH groups were significantly de-creased.Compared with FF group,ADFI and ADG in FZL,FZM and FZH groups were significantly increased(P＜0.05).Compared with CG group,the UA content in FZL,FZM and FZH groups was significantly decreased(P＜0.05),and the BUN content in FZH group was significantly decreased(P＜0.05).Compared with FF group,kidney index,UA content and BUN content in FZL,FZM and FZH groups were significantly decreased(P＜0.05),and CRE content in FZH group was significantly decreased(P＜0.05).Compared with CG group,the structure of liver and kidney in FF group was disorganized and the boundary was blurred,and the renal tissue structure in FZL,FZM and FZH groups had no significant change.Compared with CG group,SOD in FZH group was significantly increased(P＜0.05),CAT in FZM and FZH groups was significantly increased(P＜0.05).Compared with FF group,the antioxidant indexes in FZL,FZM and FZH groups were significantly de-creased(P＜0.05).Compared with FF group,the mRNA expression levels of Nrf2 and NQO-1 in FZM and FZH groups were significantly increased(P＜0.05),and the mRNA expression levels of HO-1 in FZL,FZM and FZH groups were significantly increased(P＜0.05).Compared with CG group,the mRNA expression levels of CytC and Caspase-9 in FZH group were significantly decreased(P＜0.05),the mRNA expression levels of Caspase-3 in FZM and FZH groups were significantly decreased(P＜0.05),and the mRNA expression levels of Bcl2 in FZH group were significantly increased(P＜0.05).Compared with FF group,the mRNA expression levels of CytC,Caspase-9,Caspase-3 and Bax in FZL,FZM and FZH groups were significantly decreased(P＜0.05),while the mRNA expression levels of Bcl2 in FZL,FZM and FZH groups were significantly increased(P＜0.05).Compared with CG group,the apoptosis rate of renal cells in FF group was significantly in-creased(P＜0.05).The results showed that Fuzi Lizhong oral liquid could improve the growth perfor-mance of chicks,enhance the antioxidant function of kidneys,inhibit cell apoptosis and improve the health level of chicks.关键词
雏鸡/附子理中口服液/抗氧化/细胞凋亡Key words
chick/Fuzi Lizhong oral liquid/antioxidation/cell apoptosis分类
农业科技引用本文复制引用
张琼一,张世佳,崔婵婵,董欣悦,杜西翠,包永占,史万玉,王霄..附子理中口服液对雏鸡生长性能和肾功能的影响[J].中国兽医科学,2025,55(2):272-278,7.基金项目
河北省重大科技支撑计划项目(242N2501Z) （242N2501Z）
河北省省属高校基本科研业务费研究项目(KY2024004) （KY2024004）
河北省现代农业产业技术体系创新团队建设专项(HBCT2024110202) （HBCT2024110202）
