中国畜牧兽医2025，Vol.52Issue(2)：946-958,13.DOI:10.16431/j.cnki.1671-7236.2025.02.043
脂多糖免疫应激研究进展
Research Progress on Immune Stress of LPS
摘要
Abstract
In recent years,immune stress caused by lipopolysaccharide(LPS)has become a potential threat in animal husbandry production.As a common bacterial endotoxin,LPS exhibits multiple immune activities and plays a important role in immune regulation and cell signal transduction.LPS can quickly activate the immune system of animals and triggering the secretion of various inflammatory factors such as tumor necrosis factor(TNF)and interleukin-1β(IL-1β).Moderate LPS stimulation can improve the animal's disease resistance and help it effectively fight infection and external stress.However,excessive or long-term exposure to LPS may lead to excesstive activation of the animal's immune system,cause inflammatory diseases,and even affect its production performance and health status.At present,LPS has been widely used to establish animal models related to immune stress.A deep understanding of the impact of LPS on immune stress in different animals is crucial to animal husbandry production,and is also the key to the development of veterinary drugs in the veterinary field.The author reviews the structure and function of LPS,the commonality and difference in immune stress induced by LPS in different animals,and the measures to alleviate immune stress induced by LPS.It also summarizes the establishment methods of LPS immune stress models and their applications in diseases,and provides suggestions and prospects for future research on animal immune stress induced by LPS,aiming to provide a reference for the research of LPS and the practice of animal husbandry production.关键词
脂多糖(LPS)/免疫应激/免疫调节/动物模型Key words
lipopolysaccharide(LPS)/immune stress/immune regulation/animal model分类
农业科技引用本文复制引用
陆瑞,盛辉,郭妍岩,张羽欣,姚大为,郭晓飞,阮维斌,张效生..脂多糖免疫应激研究进展[J].中国畜牧兽医,2025,52(2):946-958,13.基金项目
吉林省青年成长科技项目(20230508122RC) （20230508122RC）
天津市重点研发计划(23YFZCSN00170) （23YFZCSN00170）
天津市自然科学基金(23JCYBJC00260) （23JCYBJC00260）
天津市农业科学院种业创新项目(2024ZYCX012) （2024ZYCX012）
天津市科技计划项目(23ZYCGSN00090) （23ZYCGSN00090）
