中国药房2025，Vol.36Issue(4)：385-394,10.DOI:10.6039/j.issn.1001-0408.2025.04.01
山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识
Expert consensus on perioperative rational use and comprehensive clinical evaluation of NSAIDs in Shandong Province
摘要
Abstract
OBJECTIVE To provide a basis for the rational use of nonsteroidal anti-inflammatory drugs(NSAIDs)in the perioperative period,and provide practical methods and technical references for the evaluation and selection of NSAIDs in medical institutions.METHODS Initiated by the Affiliated Hospital of Qingdao University,Clinical Pharmacy Professional Committee of the Shandong Pharmacists Association,Clinical Individualised Drug Testing and Guidance Branch of the Shandong Medical Association,Comprehensive Clinical Medication Evaluation Working Committee of the Shandong Pharmacists Association,Pain Branch of the Shandong Medical Association in conjunction with several medical institutions in Shandong Province organized 22 pharmaceutical experts and medical experts from 17 hospitals in Shandong Province to form a consensus on the rational use and comprehensive clinical evaluation of NSAIDs in the perioperative period through the literature research method,expert interview method and questionnaire survey method based on evidence-based medicine.A comprehensive clinical evaluation was also conducted on a total of 13 specifications of 9 commonly used clinical drug varieties in Shandong Province,including celecoxib,etoricoxib,imrecoxib,ibuprofen(containing reference/original drugs and national/Shandong Province's centralized volume-based procurement varieties).RESULTS&CONCLUSIONS A consensus opinion was formed on preoperative prophylactic use and postoperative use of NSAIDs,as well as contraindications,digestive tract risk,cardiovascular system risk,bleeding risk and kidney injury risk in the perioperative period.The evaluation and selection criteria of perioperative use of NSAIDs were established,involving 6 dimensions of safety,efficacy,economy,innovation,appropriateness,and accessibility.The results of comprehensive clinical evaluation showed that the top 6 drugs(scores over 70)were Celecoxib capsules(Celebrex)and Celecoxib capsules(Naiqi),Diclofenac sodium sustained-release tablets,Etocoxib tablets(Arcoxia)and Etocoxib tablets(Qimingshu),and Parecoxib sodium for injection.With the progress of clinical research,this consensus will be further updated and adjusted,and medical institutions can combine with the practice to develop a comprehensive clinical evaluation system of NSAIDs suitable for their institutions.关键词
非甾体抗炎药/围手术期/合理用药/临床综合评价/专家共识Key words
nonsteroidal anti-inflammatory drugs/perioperative/rational drug use/comprehensive clinical evaluation/expert consensus分类
医药卫生引用本文复制引用
山东省药师协会临床药学专业委员会,山东省医学会临床个体化用药检测与指导分会,山东省药师协会药品临床综合评价工作委员会,山东省医学会疼痛学分会,荆凡波..山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识[J].中国药房,2025,36(4):385-394,10.基金项目
山东省自然科学基金面上项目(No.ZR2022MH069) （No.ZR2022MH069）
