中国药物经济学2025，Vol.20Issue(1)：41-44,4.DOI:10.12010/j.issn.1673-5846.2025.01.007
左西孟旦与多巴酚丁胺对重症瓣膜病患者围术期心功能及预后的影响
Effect of Levosimendan and Dobutamine on Perioperative Cardiac Function and Prognosis in Patients with Severe Valvular Disease
郭裕良 1袁昊尧 2陈启明 2彭晓鹏2
作者信息
- 1. 南方医科大学第十附属医院(东莞市人民医院)胸外科,广东东莞 523000
- 2. 南方医科大学第十附属医院(东莞市人民医院)心脏大血管外科,广东东莞 523000
- 折叠
摘要
Abstract
Objective To explore the effects of levosimendan and dobutamine on perioperative cardiac function and prognosis in patients with severe valvular disease.Methods A total of 80 patients with severe valvular disease who received heart valve replacement in the 10th Affiliated Hospital of Southern Medical University from January to December 2023 were selected and divided into control group and observation group according to different treatment methods,with 40 cases in each group.Both groups received conventional treatment after surgery,meanwhile,the control group was treated with dobutamine,and the observation group was treated with levosimendan on the basis of the control group.Cardiac function,levels of inflammatory factors,incidence of adverse cardiovascular events and readmission rate were compared between the two groups.Results After treatment,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and cardiac output(CO)in both groups were improved compared with those before treatment(P＜0.05),and the observation group was better than the control group(P＜0.05).After treatment,the serum levels of interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in both groups were lower than before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).The incidence of adverse cardiovascular events and re-hospitalization in the observation group were lower than those in the control group(P＜0.05).Conclusion Levosimendan combined with dobutamine in the treatment of patients with severe valvular disease can more effectively improve perioperative cardiac function,reduce the level of inflammatory factors,and decrease the incidence of adverse cardiovascular events and rehospitalisation rate compared with dobutamine alone,thus improving the prognosis of patients.关键词
左西孟旦/多巴酚丁胺/重症瓣膜病/心功能/预后Key words
Levosimendan/Dobutamine/Critical valve disease/Cardiac function/Prognosis分类
临床医学引用本文复制引用
郭裕良,袁昊尧,陈启明,彭晓鹏..左西孟旦与多巴酚丁胺对重症瓣膜病患者围术期心功能及预后的影响[J].中国药物经济学,2025,20(1):41-44,4.
