中国药物经济学2025，Vol.20Issue(1)：56-61,65,7.DOI:10.12010/j.issn.1673-5846.2025.01.010
基于网络药理学分析威麦宁胶囊治疗乳腺癌的作用机制
Analysis of the Mechanism of Action of Weimaining Capsule in the Treatment of Breast Cancer based on Network Pharmacology
顾选 1王莎 1范玛莉 1赵帅丹 1尹晓蕊 1成彦武 1李丽平1
作者信息
- 1. 国药集团北京华邈药业有限公司,北京 102600
- 折叠
摘要
Abstract
Objective To investigate the pharmacological mechanism of Weimaining capsule in the treatment of breast cancer by using a network pharmacology approach.Methods The activecomponents and potential targets of Weimaning capsule were screened out through TCMSP,and supplemented with literature.The gene expression data of BC were obtained from the GeneCards human gene database and online Mendelian Inheritance in man database(OMIM).The common targets were analyzed by Venny platform.A protein-protein interaction(PPI)network of intersection targets was constructed by STRING and visualized by Cytoscape software,and GO functional annotation and KEGG pathway enrichment analysis were performed by database for annotation,visualization and integrated discovery.Results Selecting the OB and DL as filter condition,20 active ingredients and 216 potential targets were involved.Four core components which are quercetin,gallic acid and luteolin and 29 core therapeutic targets of anti-breast cancer were obtained.The KEGG analysis showed that target genes were enriched in several key cancer-related signaling pathways,including the Pathways in cancer,HIF1 signaling pathway,PI3K-Akt signaling pathway,etc.Conclusion The effectiveness of Weimaining capsule in treating breast cancer has multiple components,targets and pathways.关键词
威麦宁胶囊/乳腺癌/网络药理学/槲皮素/没食子酸/木犀草素Key words
Weimaining capsule/Breast cancer/Network pharmacology/Quercetin/Gallic acid/Luteolin分类
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顾选,王莎,范玛莉,赵帅丹,尹晓蕊,成彦武,李丽平..基于网络药理学分析威麦宁胶囊治疗乳腺癌的作用机制[J].中国药物经济学,2025,20(1):56-61,65,7.
