中国医学装备2025，Vol.22Issue(2)：65-69,5.DOI:10.3969/j.issn.1672-8270.2025.02.012
抑郁症患者MRI脑白质病变与认知功能损害的相关性分析
Analysis of the relationship between the lesions of brain white matter in MRI and the cognitive impairment in patients with depression
摘要
Abstract
Objective:To explore the relationship between the lesions of white matter in magnetic resonance imaging(MRI)and the cognitive impairment in patients with depression.Methods:A total of 80 patients with depression who admitted to emergency general hospital from January 2022 to January 2024 were retrospectively collected.According to whether there were lesions of brain white matter,they were divided into study group(38 cases with lesions)and control group(42 cases without lesions).Results:There were significant differences in age,years of receiving education,and total course of disease between study group and control group(t=2.84,2.62,2.19,P<0.05).The scores of attention and computational ability,memory,naming,attention/concentration,language and visual spatial skills,and total score of MoCA score were respectively(2.56±0.50,2.35±0.30,3.22±1.30,2.12±0.59,1.17±0.35,1.10±0.30,1.35±0.35,13.87±1.81)in study group,all of which were significantly lower than those(3.10±0.55,2.60±0.35,4.01±1.65,2.60±0.58,1.40±0.55,1.40±0.84,1.80±0.79,16.91±2.10)in control group,and the differences of them between two groups were statistically significant(t=4.578,3.412,2.361,3.666,2.205,2.084,3.234,6.900,P<0.05).There were correlations between the lesion of brain white in MRI and the Montreal cognitive assessment(MoCA)score,between that and age,between that and years of receiving education,between that and total course of disease,and between that and Hamilton depression rating scale(HAMD)score in patients with depression(OR=2.19,0.93,1.11,0.89,1.31,P<0.05).The results of Logistic regression analysis showed that MoCA score and lesions of brain white matter in MRI had independent effects on cognitive impairment of patients with depression.Conclusion:The lesion of brain white matter is an important factor for cognitive impairment in patients with depression.关键词
抑郁症患者/磁共振成像(MRI)/脑白质病变/认知功能损害Key words
Depressed patients/Magnetic resonance imaging(MRI)/Lesion of brain white matter/Cognitive impairment分类
医药卫生引用本文复制引用
黄晓瀚,李静雅,李梦初,孙立明..抑郁症患者MRI脑白质病变与认知功能损害的相关性分析[J].中国医学装备,2025,22(2):65-69,5.基金项目
北京市卫健委市属医学科研院所公益发展改革试点项目(2023-4) Beijing Municipal Health Commission Medical Research Institute Public Welfare Development and Reform Pilot Project(2023-4) （2023-4）
