中国肿瘤生物治疗杂志2024,Vol.31Issue(12):1167-1177,11.DOI:10.3872/j.issn.1007-385x.2024.12.001
肿瘤微环境"冷热转换":细胞电池(Tesla Cell)
"Hot-cold switch"in tumor microenvironment:Tesla Cell
摘要
Abstract
Immunotherapy has provided new approaches for tumor treatment.The immune status within the tumor microenvironment of cancer patients,characterized as"cold"or"hot",determines whether they will respond to immunotherapy.This article innovatively proposes the concept of"cell batteries(or Tesla Cell)"to promote the"cold-hot switch"of the tumor microenvironment.It reviews the current research status and progress in tumor immunotherapy,focusing on the concepts of"cold tumors"and"hot tumors,"the conversion strategies between them,as well as the types and applications of"Tesla cell",aiming to provide a theoretical foundation for the development of new immunotherapeutic strategies for tumors.关键词
细胞电池/冷肿瘤/热肿瘤/肿瘤微环境/免疫治疗Key words
Tesla cell/cold tumor/hot tumor/tumor microenvironment(TME)/immunotherapy分类
医药卫生引用本文复制引用
刘颖婷,韩为东,蒋敬庭..肿瘤微环境"冷热转换":细胞电池(Tesla Cell)[J].中国肿瘤生物治疗杂志,2024,31(12):1167-1177,11.基金项目
国家自然科学基金项目(No.32270955) (No.32270955)
国家生物制药技术创新中心省级人才计划(No.NCTIB2024JS0101) (No.NCTIB2024JS0101)
江苏省重点研发计划专项资金项目临床前沿技术(No.BE2022719) (No.BE2022719)
江苏省医学重点学科(No.YXZDXK202236) (No.YXZDXK202236)
江苏省研究生科研与实践创新计划(No.KYCX23_3265) (No.KYCX23_3265)
常州市临床医学中心(No.CZZX202201) (No.CZZX202201)
南京医科大学常州医学中心重点项目(No.CMCM202401) (No.CMCM202401)
常州市卫生健康委员会重大科技项目(No.ZD202329) (No.ZD202329)
常州西太湖细胞前沿技术发展基金会重点培育项目 ()
常州市卫健委"十四五"高层次人才培养计划 ()