转化医学杂志2024，Vol.13Issue(10)：1612-1616,5.DOI:10.3639/i.issn.2095-3097.2024.10.013
依托孕烯植入剂对健康人群及合并子宫肌腺症、子宫内膜异位症人群出血模式及非避孕益处的研究
Study on Bleeding Pattern and Non-contraceptive Benefits of Etonogestrel Implants in Healthy Population and Population with Endometriosis Diseases
摘要
Abstract
Objective To investigate the effects and adverse reactions of etonogestrel implants in healthy women and women with myoadenosis and endometriosis.Methods A total of 60 women of childbearing age who received etonogestrel implants for normal contraception at Wuxi Maternal and Child Health Hospital from December 2019 to April 2023 were randomly selected as the normal group.Another 60 women of childbearing age who received etonogestrel implants for contraception combined with endometriosis or myoadenosis were selected as the control group.The implant site,contraceptive effectiveness,menstrual status,dysmenorrhea relief,uterine size,and adverse reactions after subcutaneous implantation were followed up at 3,6,and 12 months.Results(1)No unplanned pregnancies occurred at 3,6,or 12 months after the operation.(2)The incidence of amenorrhea,sparse menstruation,and reduced menstrual volume in the postoperative normal group was higher than in the control group,with statistical differences observed at 3 and 6 months(P＜0.05),but no statistical difference between the two groups at 12 months after surgery(P＞0.05).(3)The preoperative uterine size in the control group was larger than in the normal group(P＜0.05).At 3,6,and 12 months after surgery,both uterine volume and endometrial thickness decreased in both groups.In the control group,differences compared with pre-treatment were statistically significant(P＜0.05),while in the normal group,there were no statistically significant differences(P＞0.05).No significant changes in ovarian cysts were observed between the two groups compared with before surgery(P＞0.05).(4)Dysmenorrhea relief showed statistical differences between the control group and the preoperative group at different time points(P＜0.05).In the normal group,only the 6-month and 12-month time points showed statistically significant differences compared to preoperative measures(P＜0.05).(5)Adverse reactions mainly included weight gain,acne,and breast tenderness.Conclusion Etonogestrel subcutaneous implants are highly effective for contraception and can significantly improve dysmenorrhea and heavy menstruation symptoms in women of childbearing age,especially in patients with myoadenosis and endometriosis.关键词
子宫肌腺症/子宫内膜异位症/依托孕烯/皮下埋置/避孕效果/药物相关性副作用和不良反应Key words
Adenomyosis/Endometriosis/Etonogestrel/Subcutaneous implantation/Contraceptive effectiveness/Drug-related side effects and adverse reactions分类
医药卫生引用本文复制引用
尹婷婷,徐丽丽,沈晔..依托孕烯植入剂对健康人群及合并子宫肌腺症、子宫内膜异位症人群出血模式及非避孕益处的研究[J].转化医学杂志,2024,13(10):1612-1616,5.基金项目
第三周期省妇幼健康重点学科(SFY3-JS2021) （SFY3-JS2021）
无锡市卫生健康委重大科研项目(Z202104) （Z202104）
无锡市卫生健康委科技成果与适宜技术推广项目(T202115) （T202115）
无锡市妇幼保健院"三名"战略"菁才计划"人才项目(LJ2023003) （LJ2023003）
"白求恩·医学科学研究基金"项目(KY202301-14) （KY202301-14）
无锡市卫生健康委妇幼健康科研面上项目(FYKY202303) （FYKY202303）
