神经药理学报2024，Vol.14Issue(5)：37-41,5.DOI:10.3969/j.issn.2095-1396.2024.05.005
甲泼尼龙与多西环素联合治疗方案用于肺炎支原体肺炎患儿对炎性因子及氧化应激指标的影响
The Effects of A Combination Therapy of Methylprednisolone and Doxycycline on Inflammatory Factors and Oxidative Stress Indicators in Children with Mycoplasma Pneumoniae Pneumonia
盛文才 1周月1
作者信息
- 1. 南通大学第六附属医院盐城市第三人民医院,盐城,224008,中国
- 折叠
摘要
Abstract
Objective:To analyze the effectiveness of a combination therapy of methylprednisolone and doxycycline in children with Mycoplasma pneumoniae pneumonia and to explore its impact on inflammatory factors and oxidative stress indicators.Methods:A total of 200 children with Mycoplasma pneumoniae pneumonia treated in our hospital from May 2021 to May 2023 were selected and randomly divided into two groups.The control group(n=100)received doxycycline monotherapy,while the observation group(n=100)received a combination therapy of methylprednisolone and doxycycline.The therapeutic effects,levels of inflammatory factors,oxidative stress levels,and adverse drug reactions were compared between the two groups.Results:After a two-week treatment period,the overall effective rate of treatment in the observation group was higher than that in the control group.Levels of inflammatory factors(CRP,TNF-α,IL-8)in the observation group were lower than those in the control group.Oxidative stress indicators showed that LPO levels were lower,while ALB and TBIL levels were higher in the observation group compared to the control group.These differences were statistically significant(P<0.05).However,there was no statistical significance in the comparison of adverse drug reactions between the two groups(P>0.05).Conclusion:The combination therapy of methylprednisolone and doxycycline effectively regulates the levels of inflammatory factors and oxidative stress indicators in children with Mycoplasma pneumoniae pneumonia,achieving remarkable therapeutic effects with high safety.关键词
肺炎支原体肺炎/甲泼尼龙/多西环素/联合治疗/炎性因子/氧化应激Key words
mycoplasma pneumoniae pneumonia/methylprednisolone/doxycycline/combination therapy/inflammatory factors/oxidative stress分类
医药卫生引用本文复制引用
盛文才,周月..甲泼尼龙与多西环素联合治疗方案用于肺炎支原体肺炎患儿对炎性因子及氧化应激指标的影响[J].神经药理学报,2024,14(5):37-41,5.
