神经药理学报2024，Vol.14Issue(5)：47-56,10.DOI:10.3969/j.issn.2095-1396.2024.05.007
阿尔茨海默症的代谢组学研究进展
Recent Progress in the Metabolomics of Alzheimer's Disease
摘要
Abstract
Alzheimer's disease is a complex neurodegenerative disorder whose exact etiology is still not fully understood.In recent years,the application of metabolomics has provided new perspectives to unravel the complex biological mechanisms of Alzheimer's disease.By quantitatively analyzing a comprehensive range of metabolites in biological samples,researchers are able to identify metabolic changes associated with Alzheimer's disease,providing data to support the exploration of potential diagnostic markers and therapeutic targets.This paper reviews research advances in metabolomics in revealing metabolic changes,identifying biomarkers,and detection tools for Alzheimer's disease.Metabolomics studies have confirmed the presence of reduced brain energy metabolism,abnormal membrane phospholipid metabolism,and imbalances in pathways related to lipid,amino acid,and choline metabolism in patients with AD.These findings emphasize the importance of metabolomics in AD and provide valuable information for future research directions and clinical diagnosis.关键词
阿尔茨海默症/代谢组学/生物标志物Key words
Alzheimer's disease/metabolomics/biomarkers分类
医药卫生引用本文复制引用
张鑫,姚思凡,马梦凡,沈丽霞..阿尔茨海默症的代谢组学研究进展[J].神经药理学报,2024,14(5):47-56,10.基金项目
河北省自然科学基金项目(No.H2019405057),河北省研究生创新资助项目(No.CXZZSS2022145),河北省高等学校科学技术研究项目(No.ZD2020136) （No.H2019405057）
