神经药理学报2024，Vol.14Issue(6)：31-35,5.DOI:10.3969/j.issn.2095-1396.2024.06.004
四肢不自主运动为首发症状早期合并构音障碍的亨廷顿病1例
A Case of Huntington's Disease with Involuntary Movements of the Limbs as the First Symptom Combined with Dysarthria in the Early Stages of the Disease
李慧 1杨金水 2薛茜2
作者信息
- 1. 河北北方学院研究生学院,张家口,075000,中国
- 2. 河北北方学院附属第一医院神经内科,张家口,075000,中国
- 折叠
摘要
Abstract
Objective:To investigate the clinical characteristics of patients with Huntington's disease patients,especially the atypical clinical symptoms,to deepen the understanding of the clinical characteristics of Huntington's disease.Methods:The clinical data of one HD patient admitted to the Department of Neurology of the First Hospital Affiliated to Hebei North College in January 2022 were collected under the principle of patient's informed and voluntary consent,and the relevant literature was reviewed and followed up.Results:Two members of this patient's family had already developed symptoms of involuntary limb movements,and this pre-documented person had early comorbid dysarthria with a CAG copy number of 43,and it was understood from the relevant literature review that speech alterations are an early symptom of HD,which may precede the onset of other motor and cognitive symptoms.Conclusion:The vast majority of HD has a positive family history and is clinically characterised by slowly progressive chorea,psychotic disorders and dementia,with speech alterations in the early stages and dysarthria and dysphagia in the later stages.关键词
亨廷顿病/临床表现/构音障碍/早期诊断Key words
Huntington's disease/clinical manifestations/dysarthria/early diagnosis分类
医药卫生引用本文复制引用
李慧,杨金水,薛茜..四肢不自主运动为首发症状早期合并构音障碍的亨廷顿病1例[J].神经药理学报,2024,14(6):31-35,5.
