肿瘤药学2024，Vol.14Issue(6)：707-715,9.DOI:10.3969/j.issn.2095-1264.2024.06.09
靶向Trop2 CAR-T治疗肺腺癌的研究进展
Research progress of Trop2-targeted CAR-T in the treatment of lung adenocarcinoma
摘要
Abstract
This review discusses the progress of chimeric antigen receptor T-cell(CAR-T)therapy targeting Trop2 in the treatment of lung adenocarcinoma(LUAD).Trop2 is a protein overexpressed in various tumors,especially in LUAD.It is associated with the disease progression and high recurrence rates.The CAR-T therapy,which involves genetically engi-neered T cells targeting Trop2,shows significant therapeutic potential in the treatment of LUAD.This article mainly dis-cusses how to improve the specificity and safety of Trop2-targeted CAR-T therapy,and how to combine it with other drugs such as antibody drug conjugate(ADC),to make it applied to the treatment of more tumors.关键词
肺腺癌/Trop2/ADC/CAR-TKey words
Trop2/Adenocarcinoma of the lung/ADC/CAR-T分类
医药卫生引用本文复制引用
蔡新培,高锦莉,徐芹芹..靶向Trop2 CAR-T治疗肺腺癌的研究进展[J].肿瘤药学,2024,14(6):707-715,9.基金项目
青海省科学技术厅面上基金资助项目(2021-38). （2021-38）
