中国中西医结合杂志2025，Vol.45Issue(1)：18-24,7.DOI:10.7661/j.cjim.20241211.157
中医分阶段论治理念联合化疗治疗转移性结直肠癌队列研究
Cohort Study on Metastatic Colorectal Cancer with Staged Treatment of Chinese Medicine and Chemotherapy
摘要
Abstract
Objective To explore the survival benefits of the concept of staged treatment of Chinese medicine(ST-CM)combined with chemotherapy in patients with metastatic colorectal cancer(mCRC).Methods Using a bidirectional cohort study method,patients with mCRC who received chemotherapy and"continuously received ≥ 3 months of ST-CM"were considered as the exposure factor.Patients who meet this exposure factor were included in the integrative medicine cohort(Group A),receiving conventional treatment combined with ST-CM;those who do not meet this exposure factor were included in the Western medicine cohort(Group B),receiving conventional treatment.The overall survival(OS)and survival rates from the 1st,2nd,and 3rd year were compared between the two groups.Results A total of 519 patients were recruited in this study.The median overall survival(mOS)for cohort A(324 cases)and cohort B(195 cases)were 34.3 months and 21.3 months,respectively(HR 0.65,95％CI:0.535-0.793,P＜0.001).The survival rates at 1st,2nd and 3rd years for Group A and Group B were 95.6％and 83.2％,38.6％and 24.7％,21.6％and 12.4％,respectively,with group A showing better outcomes than group B(P＜0.001).Subgroup analysis revealed that regardless of gender,primary tumor site,genetic type,combination with targeted therapy,presence of liver metastasis,and absence of peritoneal metastasis,Group A's mOS was significantly better than Group B,with all differences being statistically significant(P＜0.05).Conclusion ST-CM combined with chemotherapy can prolong the OS of mCRC patients,and improve the survival rates from the 1st,2nd and 3rd year.(Chinese Clinical Trial Registry No.ChiCTR-ORC-17010497)关键词
转移性结直肠癌/中西医结合/分阶段论治/化疗/生存期/队列研究Key words
metastatic colorectal cancer/integrative medicine/staged treatment of Chinese medicine/chemotherapy/survival/cohort study引用本文复制引用
张彤,唐末,陈悦,翟嘉威,杨宇飞..中医分阶段论治理念联合化疗治疗转移性结直肠癌队列研究[J].中国中西医结合杂志,2025,45(1):18-24,7.基金项目
中国中医科学院科技创新工程(No.CI2021A01811) （No.CI2021A01811）
国家自然科学基金资助项目(No.82174461) （No.82174461）
中国中医科学院西苑医院提升中医药临床循证证据级别研究专项(No.XYZX0201-22) （No.XYZX0201-22）
