中国中西医结合杂志2025，Vol.45Issue(1)：25-31,7.DOI:10.7661/j.cjim.20241217.166
益气导滞方促进胃癌术后胃肠功能恢复随机对照研究
Yiqi Daozhi Formula Promotes Gastrointestinal Function Recovery after Gastric Cancer Surgery:A Randomized Controlled Trial
摘要
Abstract
Objective To study efficacy and safety of Yiqi Daozhi Formula in the recovery of gastrointestinal function after gastric cancer surgery.Methods A total of 67 patients undergoing laparoscopic radical gastrectomy between April 2023 and April 2024 were selected and randomly assigned to a treatment group(33 cases)and a control group(34 cases)using a random number method.Both groups received perioperative management based on the Enhanced Recovery After Surgery(ERAS)protocol,with data collected using artificial intelligence-powered wearable electrocardiogram(ECG)recorders and continuous bowel sound auscultation recorders.The treatment group received 100 mL of concentrated Yiqi Daozhi Formula orally from the 1st to 3rd postoperative day,whereas the the control group reveived equal volume of plain water daily over the same period.Key indicators of gastrointestinal recovery encompassed the time to first flatus,bowel sound recovery,semi-liquid diet tolerance,pain scores on on the 3rd postoperative day,and length of hospital stay,which were compared between the groups.Additionally,postoperative heart rate variability(HRV)indices,including standard diviation of NN intervals(SDNN),standard deviation of the average NN intervals(SDANN),percentage of difference between adjacent normal R-R intervals exceeding 50 milliseconds(pNN50),low frequency(LF),and high frequency(HF)were evaluated.Inflammatory biomarkers such as high-sensitivity C-reactive protein(hs-CRP),white blood cell(WBC),interleukin(IL)-1 β,IL-2,IL-6,tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)were assessed,alongside the incidence of postoperative complications.Results Compared to the control group,the treatment group exhibited reduced bowel sound recovery time and earlier onset of first flatus(P=0.001).On the 1st postoperative day,the treatment group exhibited decreased levels of hs-CRP,WBC,IL-1β,and IL-2(P＜0.001,P＜0.05).By the 3rd postoperative day,the treatment group continued to show lower levels of hs-CRP,IL-1 β,and IL-2(P＜0.001,P＜0.05).Furthermore,the treatment group showed higher indices,specifically SDNN,SDANN,pNN50,and LF,on the third postoperative day(P＜0.01,P＜0.05).Conclusion The application of Yiqi Daozhi Formula post-gastrectomy in patients with gastric cancer surgery is safety,and associated with reduced postoperative inflammatory responses,improved autonomic nervous function,and facilitated early gastrointestinal function recovery.(ClinicalTrials.gov Registration No.NCTO3121729)关键词
胃癌/益气导滞方/中药复方/胃肠功能/心率变异性/肠鸣音/人工智能/随机对照试验/中西医结合Key words
gastric cancer/Yiqi Daozhi Formula/Chinese herbal compound/gastrointestinal function/heart rate variability/bowel sounds/artificial intelligence/randomized controlled trial/integrative medicine引用本文复制引用
南海鸥,蔡雨玲,徐鹏演,李嘉宇,朱永康,江志伟,王刚..益气导滞方促进胃癌术后胃肠功能恢复随机对照研究[J].中国中西医结合杂志,2025,45(1):25-31,7.基金项目
江苏省重点学科项目(No.ZDXK202251) （No.ZDXK202251）
江苏省中医院人才引进项目(No.grjj0250) （No.grjj0250）
