中国中西医结合杂志2025，Vol.45Issue(1)：42-49,8.DOI:10.7661/j.cjim.20241215.163
益气养阴中成药治疗IgA肾病疗效及影响因素
Efficacy and Influencing Factors of Qi-benefiting and Yin-nourishing Chinese Patent Medicines for IgA Nephropathy
摘要
Abstract
Objective To observe the long-term efficacy of qi-benefiting and yin-nourishing Chinese patent medicines(QYP)for IgA nephropathy(IgAN).Methods Two thousand patients with primary IgAN diagnosed by renal biopsy at three hospitals were included in this study.Patients were assigned to a treatment group and a control group based on the administration of QYP.Demographic data,pathological outcomes,and differences in Chinese medicine syndromes between the two groups were compared.To control for confounding factors,a 1∶1 propensity score matching method was used to match patients,and a multivariate Logistic regression analysis was conducted to explore the factors influencing the efficacy of QYP.Results Among 2 000 patients with primary IgAN,491 patients were treated with QYP,while 1 509 cases served as the control group.After matching propensity scores between groups,228 cases were included in each group.The median age of patients in the treatment group was 35.5 years(interquartile range:28.0,44.0),urine protein quantification was 1.2(0.7,1.9)g/d,and the eGFR was 84.6(61.2,107.0)mL/min/1.73 m2,the follow-up period was was 32.0(12.0,62.0)months,a total of 21 patients(9.2％)experienced deterioration in renal function after treatment.In the control group,the median age was 34.0(27.0,43.0)years,urine protein quantification was 1.2(0.7,2.1)g/d,and eGFR was 84.8(56.2,112.2)mL/min/1.73 m2,the follow-up period was 30.5(12.0,54.8)months,a total of 35 patients(15.4％)experienced deterioration in renal function after treatment.The difference in the rate of renal function deterioration between the two groups was statistically significant(P＜0.05).Multivariable Logistic regression analysis showed that patients with qi and yin deficiency syndrome(OR 1.972,95％CI:1.162-3.346),damp-heat syndrome(OR 1.862,95％CI:1.093-3.172)and those with crescent formation(OR 1.067,95％CI:1.020-1.115)were more likely to achieve clinical remission with the use of QYP.Conclusions QYP delays the deterioration of renal function.Treatment with the application of QYP,particularly for patients with damp-heat syndrome and crescentic formation,can facilitate clinical remission in IgAN patients.(Chinese Clinical Trial Registry No.ChiCTR2200055905)关键词
IgA肾病/中成药/益气养阴法/辨证施治/疗效/影响因素/中西医结合Key words
IgA nephropathy/Chinese patent medicines/qi-benefiting and yin-nourishing method/treatment based on syndrome differentiation/therapeutic effect/influencing factor/integrative medicine引用本文复制引用
段姝伟,陈香美,张守琳,林启展,姚进,邹迪,柯江华,刘林昌,郑颖,董哲毅..益气养阴中成药治疗IgA肾病疗效及影响因素[J].中国中西医结合杂志,2025,45(1):42-49,8.基金项目
国家重点研发计划(No.2019YFC1709903) （No.2019YFC1709903）
北京市科技计划课题(No.D181100000118002) （No.D181100000118002）
