中国中西医结合杂志2025，Vol.45Issue(1)：50-55,6.DOI:10.7661/j.cjim.20241125.153
帕金森病姿势步态障碍中医证候要素特征及相关性
Characteristics and Correlations of Chinese Medicine Syndrome Elements in Postural Instability and Gait Difficulties of Parkinson's Disease
摘要
Abstract
Objective To explore the characteristics and differences in Chinese medicine(CM)syndrome elements among patients with different motor subtypes of Parkinson's disease(PD),and the correlations between CM syndrome elements and the postural instability and gait difficulty(PIGD)subtype.Methods Clinical data and CM syndrome elements information were collected from 96 primary PD patients at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine,over the period from August 2022 to December 2023.The patients were assigned to two groups:PIGD type(43 cases)and non-PIGD type(53 cases).During the research,T-tests,U-tests,X2 tests,or Fisher's exact tests were used to analyze differences in CM syndrome elements between the groups.Besides,Binary logistic regression was employed to assess the correlations between CM syndrome elements and the PIGD phenotype.Results Compared with the non-PIGD group,individuals with PIGD exhibited a higher prevalence of freezing of gait(FOG)(P＜0.001),lower scores on Montreal Cognitive Assessment(MoCA)(P=0.042),and higher levodopa equivalent daily doses(P=0.009).The predominant CM syndrome elements in the PIGD group were Shen deficiency(40/43,93.0％),qi deficiency(35/43,81.4％),Pi deficiency(34/43,79.1％),yin deficiency(29/43,67.4％),and blood deficiency(27/43,62.8％).Compared with the non-PIGD group,the incidence of Shen deficiency(P=0.022),Pi deficiency(P＜0.001),qi deficiency(P=0.006),and blood deficiency(P=0.001)was significantly higher in the PIGD group,whereas the incidence of Gan wind was significantly lower(P＜0.001).Regression analysis revealed a positive correlation between blood deficiency(OR=5.383,P=0.037)and the PIGD subtype,while Gan wind was negatively correlated with it(OR=0.016,P＜0.001).Conclusions There are differences in the distribution of CM syndrome elements among different motor subtypes of PD.The PIGD subtype is mainly characterized by deficiencies in Shen,qi,Pi,yin,and blood.Blood deficiency,exhibits a positive correlation with the PIGD phenotype,whereas Gan wind shows a negative correlation.关键词
帕金森病/颤病/中医证候要素/姿势步态障碍/相关性分析/横断面研究/中西医结合Key words
Parkinson's disease/tremor syndrome/CM syndrome elements/postural instability/gait difficulty/correlation analysis/cross-sectional study/integrative medicine引用本文复制引用
王玉,梅家宁,赵红苹,韦紫君,韩雪怡,张云云..帕金森病姿势步态障碍中医证候要素特征及相关性[J].中国中西医结合杂志,2025,45(1):50-55,6.基金项目
上海市中医药三年行动计划(No.ZY3-FWMS-1-1001-YY) （No.ZY3-FWMS-1-1001-YY）
上海市科学技术委员会项目(No.21Y31920300) （No.21Y31920300）
