中国中西医结合杂志2025，Vol.45Issue(2)：146-152,7.DOI:10.7661/j.cjim.20250113.032
脾胃培源方治疗脾胃虚弱型慢性萎缩性胃炎伴肠上皮化生随机对照研究
Treatment of Chronic Atrophic Gastritis with Pi-Wei Weakness Type Accompanied with Intestinal Metaplasia by Piwei Peiyuan Decoction:A Randomized Controlled Trial
摘要
Abstract
Objective To observe the therapeutic effect of Piwei Peiyuan Decoction(PWPYD)in treating chronic atrophic gastritis patients with Pi-Wei weakness type accompanied with intestinal metaplasia.Methods A total of 100 chronic atrophic gastritis patients with Pi-Wei weakness type accompanied with intestinal metaplasia were included in this study from June 2022 to December 2023 at the Second Affiliated Hospital of Anhui University of Chinese Medicine.Totally 96 patients met the inclusion criteria and were randomly assigned to the control group and the treatment group,48 cases in each group.The patients in the treatment group were treated with PWPYD,and those in the control group were treated with folic acid tablets.The treatment course lasted for 24 weeks.The changes of pathological scores,Chinese medicine(CM)symptom scores,and gastroscopic scores,serum pepsinogen Ⅰ(PG Ⅰ),pepsinogen Ⅱ(PG Ⅱ),gastrin-17(G-17),interleukin-6(IL-6),IL-10,and tumor Necrosis factor-Alpha(TNF-α)levels were observed before and after treatment between the two groups.Meanwhile,Western Blot and RT-qPCR were used to detect the levels of cystine glutamate reverse transporter(xCT),glutathione eroxidase 4(GPX4),and peroxisome proliferator activated receptor α(PPARα)expressions.Results Compared with baseline,pathological scores,CM symptom scores,and gastroscopic scores decreased in the two group after treatment(P＜0.05).The serum PG Ⅰ,PGⅡ,G-17,and IL-10 expression levels increased(P＜0.05),and the serum IL-6 and TNF-α expression levels decreased(P＜0.05).The protein and mRNA levels of xCT,GPX4,and PPARα in the focal tissue decreased(P＜0.05).Compared with the control group after treatment,pathological scores and gastroscopic scores of mucous membrane color,mucous membrane texture decreased(P＜0.05),CM symptom scores of gastric distension and fullness,gastric pain,low food intake and nausea,fatigue and weakness,and shortness of breath and laziness decreased in the treatment group(P＜0.05).The expression levels of serum PG Ⅰ,G-17,IL-6,IL-10,and TNF-α in the treatment group were better than in the control group(P＜0.05).The protein and mRNA levels of xCT,GPX4,and PPARα in lesion tissues in the treatment group were lower than those in the control group(P＜0.05).Conclusion By regulating the expression levels of serum inflammatory factors and the protein and mRNA expression levels of xCT,GPX4,and PPARα in the lesion tissue,PWPYD can improve the clinical symptoms and pathological changes of the gastric mucosa of the patients,and improve their quality of life.关键词
慢性萎缩性胃炎/肠上皮化生/脾胃培源方/疗效观察/中药复方/随机对照试验Key words
chronic atrophic gastritis/intestinal metaplasia/Piwei Peiyuan Decoction/therapeutic effect observation/Chinese herbal compound/randomized controlled trial引用本文复制引用
裴蓓,孙琴,丁文静,吴凯瑞,李学军..脾胃培源方治疗脾胃虚弱型慢性萎缩性胃炎伴肠上皮化生随机对照研究[J].中国中西医结合杂志,2025,45(2):146-152,7.基金项目
安徽省重大疑难疾病中西医协同攻关项目(No.0708-2021) （No.0708-2021）
