中国中西医结合杂志2025，Vol.45Issue(2)：162-168,7.DOI:10.7661/j.cjim.20241125.184
急性心肌梗死合并焦虑抑郁中医证素分布及相关临床特征回顾性研究
Retrospective Study on the Distribution of Chinese Medicine Syndrome Elements and Related Clinical Characteristics in Patients with Acute Myocardial Infarction Combined with Anxiety and Depression
摘要
Abstract
Objective To observe the distribution of Chinese medicine(CM)syndrome elements and related clinical characteristics in patients with acute myocardial infraction(AMI)combined with anxiety and depression,and to explore the related risk factors.Methods A retrospective study was conducted on patients with AMI hospitalized from September 2019 to September 2022 at Xiyuan Hospital,China Academy of Chinese Medical Sciences.And 1 392 patients met the inclusion criteria and were assigned to the AMI-alone group(1 300 cases)and the AMI combined with anxiety and depression group(92 cases)based on the presence or absence of anxiety and depression.Furthermore,the patients were assigned to subgroups according to the type of AMI:acute ST-segment elevation myocardial infarction(STEMI)and acute non-ST-segment elevation myocardial infarction(NSTEMI).General information,CM syndrome elements,cardiac ultrasound indicators,and serum biomarkers were collected.Univariate analysis was performed to identify significant differences in clinical characteristics between AMI patients with and without anxiety and depression.Binary Logistic regression was then employed to analyze whether these differential clinical characteristics served as risk factors for anxiety and depression.Results In terms of CM syndrome elements,the AMI-alone group was mainly characterized by blood stasis and phlegm turbidity,while the AMI with anxiety and depression group primarily exhibited blood stasis and qi deficiency.Univariate analysis showed statistically significant differences in gender,marital status,smoking history,insomnia,heart failure,arrhythmia,NT-proBNP levels,and Killip classification between the two groups(P＜0.05).Logistic regression identified abnormal marital status[OR 2.949,95％CI(1.514～5.741),P=0.001]and insomnia[OR 2.934,95％CI(1.788～4.816),P=0.000]as independent risk factors for anxiety and depression in AMI patients.Subgroup analysis showed that female,abnormal marital status,insomnia,and arrhythmia were independent risk factors for anxiety and depression in NSTEMI patients.Conclusions Abnormal marital status and insomnia were independent risk factors for anxiety and depression in AMI patients.Additionally,female and arrhythmia were also independent risk factors for anxiety and depression in NSTEMI patients.关键词
急性心肌梗死/焦虑/抑郁/中医证素/中西医结合/回归分析/回顾性研究Key words
acute myocardial infarction/anxiety/depression/Chinese medicine syndrome elements/integrative medicine/regression analysis/retrospective study引用本文复制引用
徐嘉唯,刘剑刚,陈露莹,张京春,蒋跃绒..急性心肌梗死合并焦虑抑郁中医证素分布及相关临床特征回顾性研究[J].中国中西医结合杂志,2025,45(2):162-168,7.基金项目
中国中医科学院科技创新工程重大攻关项目(No.CI2021A00908) （No.CI2021A00908）
全国中医临床优秀人才项目(No.国中医药人教函[2022]1号) （No.国中医药人教函[2022]1号）
