中药新药与临床药理2025，Vol.36Issue(2)：214-218,5.DOI:10.19378/j.issn.1003-9783.2025.02.007
苍术野生品与栽培品的药效学比较
Comparative Study on Pharmacodynamics of Wild and Cultivated Atractylodes chinensis
摘要
Abstract
Objective To compare the pharmacodynamic differences between wild and cultivated Atractylodes chinensis from Jilin based on the traditional efficacy of invigorating the spleen and removing dampness,and dispeling wind and cold.Methods The analgesic effects of wild and cultivated Atractylodes chinensis were studied by acetic acid-induced body twisting method.The anti-inflammatory effects of wild and cultivated Atractylodes chinensis were studied using mice model of ear swelling induced by xylene and granuloma.The advancing distance of the ink in the small intestine of mice was calculated.The model of gastric ulcer induced by hydrochloric acid(0.6 mol·L-1)was established to study the therapeutic effect of wild and cultivated Atractylodes chinensis on gastric ulcer.The low-,medium-and high-doses of Atractylodes chinensis decoction administered orally to mice were 1.5,3,6 g·kg-1,respectively.The rats were orally treated with low-,medium-and high-doses of Atractylodes chinensis decotciton(1,2,4 g·kg-1).Results Compared with model group,the mice in high-dose of wild Atractylodes chinensis,medium-and high-doses of cultivated Atractylodes chinensis groups revealed significant reduction of the number of twisting and increasement of the analgesic rate(P<0.05,P<0.01).The degree of ear swelling was significantly reduced,and the inhibition rate was obviously increased(P<0.05,P<0.01).It was found that the size of the granulomas of mice in medium-and high-doses of wild and cultivated Atractylodes chinensis groups was significantly reduced,and the inhibition rate was obviously increased(P<0.05,P<0.01).Ink propulsion rate was significantly increased(P<0.05,P<0.01).The ulcer area of rats in in medium-and high-doses of wild and cultivated Atractylodes chinensis groups were significantly reduced,and the inhibition rate was significantly increased(P<0.01).There was no significant difference in analgesia,anti-inflammation,small intestine propulsion function and anti-gastric ulcer between wild and cultivated Atractylodes chinensis at the same dose(P>0.05).Conclusion Wild Atractylodes chinensis and cultivated Atractylodes chinensis in Jilin had outstanding effect in analgesia,anti-inflammation,intestinal propulsion and anti-gastric ulcer,and there was no pharmacodynamic differences between the two Atractylodes chinensis at the same dose.关键词
野生苍术/栽培苍术/药效差异/镇痛/抗炎/肠推进/抗胃溃疡/小鼠/大鼠Key words
Wild Atractylodes chinensis/cultivated Atractylodes chinensis/pharmacodynamic differences/analgesia/anti-inflammation/intestinal propulsion/anti-gastric ulcer/mice/rats分类
医药卫生引用本文复制引用
林智,王心荷,张文静,王雨辰,律广富,孙铭阳,林贺,林喆..苍术野生品与栽培品的药效学比较[J].中药新药与临床药理,2025,36(2):214-218,5.基金项目
吉林省科技发展计划项目(20210204014YY). （20210204014YY）
