中国现代中药2025，Vol.27Issue(2)：210-218,9.DOI:10.13313/j.issn.1673-4890.20231101002
基于UHPLC-Q-Exactive Orbitrap MS技术的天山雪莲口服液化学成分快速表征
Rapid Identification of Chemical Constituents in Sasussured Involucrata Oral Liquid Based on UHPLC-Q-Exactive Orbitrap MS Technology
摘要
Abstract
Objective:To identify the main chemical constituents of Sasussured involucrata oral liquid by using UHPLC-Q-Exactive Orbitrap MS technology and clarify the material basis.Methods:Waters ACQUITY UPLC BEH C18 chromatographic column(100 mm×2.1 mm,1.7 µm)was used,with 0.1%formic acid(A)-acetonitrile(B)as mobile phase for gradient elution.An electrospray ionization(ESI)source was used and operated in both positive and negative ion modes.Results:A total of 48 chemical constituents were identified by comparing the reference standards,databases,and bibliography data,44 of those were reported in Sasussured involucrata oral liquid for the first time,and 18 chemical constituents were accurately identified.Conclusion:The method can rapidly and effectively identify the main chemical constituents of Sasussured involucrata oral liquid,laying a foundation for research on its quality control,effective components,and mechanism of action.关键词
天山雪莲/化学成分/超高效液相色谱-四级杆-静电场轨道阱质谱法Key words
Saussurea involucrata(Kar.et Kir.)Sch.-Bip./chemical constituents/UHPLC-Q-Exactive Orbitrap MS分类
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李凯琳,刘玲,邹宇凤,陈逸凡,唐才俊,杨建波..基于UHPLC-Q-Exactive Orbitrap MS技术的天山雪莲口服液化学成分快速表征[J].中国现代中药,2025,27(2):210-218,9.基金项目
新疆维吾尔自治区智力援疆创新拓展人才计划项目 （）
