北京中医药大学学报2025，Vol.48Issue(2)：253-269,17.DOI:10.3969/j.issn.1006-2157.2025.02.016
原发性痛经寒凝血瘀证相关腧穴体表微循环敏化研究
Study on surface microcirculation sensitization of acupuncture points related to cold coagulation and stasis syndrome in primary dysmenorrhea
摘要
Abstract
Objective To assess the dynamic changes of microcirculation at acupoints in patients with primary dysmenorrhea and cold congelation and blood stasis syndrome using laser speckle blood flow imaging.Methods Patients with primary dysmenorrhea and cold coagulation and blood stasis syndrome(primary dysmenorrhea group,n=53)and healthy female college students(control group,n=57)who met the inclusion and exclusion criteria from October 2020 to July 2022 were enrolled at Hebei University of Chinese Medicine.On the premenstrual and first day of menstruation,a laser speckle blood flow imaging system was used to measure the microcirculation blood flow perfusion on the surface of acupoints related to the conception,thoroughfare,and governor vessels,and stomach,spleen,and bladder meridians in the abdomen and lumbosacral regions.The dynamic changes in microcirculation were calculated based on the difference in average blood flow perfusion at each acupoint before and after menstruation.Receiver operating curve(ROC)analysis was used to analyze the diagnostic efficacy of dynamic changes in microcirculation on the surface of each acupoint.The microcirculation sensitization rate of acupoints was calculated.Results Compared with the control group,the dynamic changes in microcirculation at the following acupoints in the primary dysmenorrhea group were increased(P<0.05):conception vessel(Yinjiao[CV7],Qihai[CV6],Shimen[CV5],Guanyuan[CV4]);left thoroughfare vessel(left Huangshu[KI16],left Zhongzhu[KI15],left Siman[KI14],left Qixue[KI13],left Dahe[KI12],left Henggu[KI11]);left stomach meridian(left Tianshu[ST25],left Wailing[ST26],left Qichong[ST30]);left spleen meridian(left Daheng[SP15],left Fujie[SP14]);right thoroughfare vessel(right Huangshu[KI16],right Zhongzhu[KI15],right Siman[KI14],right Qixue[KI13],right Dahe[KI12],right Henggu[KI11]);right stomach meridian(right Wailing[ST26],right Daju[ST27],right Shuidao[ST28],right Guilai[ST29],right Qichong[ST30]);and right spleen meridian(right Fujie[SP14]).The area under the ROC curve of conception vessel(Yinjiao[CV7],Qihai[CV6],Shimen[CV5],Guanyuan[CV4]),thoroughfare vessel(right Siman[KI14],left Huangshu[KI16],right Qixue[KI13],right Zhongzhu[KI15],right Dahe[KI12],left Zhongzhu[KI15],left Siman[KI14],right Huangshu[KI16],left Qixue[KI13],right Henggu[KI11],left Henggu[KI11],left Dahe[KI12]);stomach meridian(left Tianshu[ST25],right Guilai[ST29],left Wailing[ST26],right Shuidao[ST28],right Daju[ST27],right Wailing[ST26],right Qichong[ST30],left Qichong[ST30]),and spleen meridian(left Daheng[SP15],left Fujie[SP14],right Fujie[SP14])was 0.610-0.682(P<0.05).Compared with the control group,the sensitization rate of some acupoints in the primary dysmenorrhea group increased(P<0.05).Conclusion With the onset of menstruation,the blood flow perfusion of some acupoints in the abdomen(thoroughfare,and conception vessels,and stomach and spleen meridians)of patients with primary dysmenorrhea and cold blood coagulation and blood stasis syndrome increased,and the status of acupoints changed from a resting state to an active state.These acupoints are sensitive in patients with primary dysmenorrhea and cold blood coagulation and blood stasis syndrome and have a certain diagnostic efficacy,providing a basis for further analyzing the efficacy and mechanism of acupuncture and moxibustion to treat primary dysmenorrhea with cold blood coagulation and blood stasis syndrome.关键词
原发性痛经/寒凝血瘀证/穴位敏化/激光散斑血流成像技术/血流灌注量Key words
primary dysmenorrhea/cold coagulation and blood stasis syndrome/acupoint sensitization/laser speckle flow imaging/blood perfusion volume分类
医药卫生引用本文复制引用
李旭欣,范玺胜,刘君,张俊茶,佘延芬,王雪松,林杪,张明健,高渊博,张细芬,陈豪,李海平,郑晓军..原发性痛经寒凝血瘀证相关腧穴体表微循环敏化研究[J].北京中医药大学学报,2025,48(2):253-269,17.基金项目
国家自然科学基金项目(No.82474395,No.81973755) （No.82474395,No.81973755）
河北中医药大学研究生创新课题(No.XCXZZBS2024005) National Natural Science Foundation of China(Nos.82474395 and 81973755) （No.XCXZZBS2024005）
