北京中医药大学学报2025，Vol.48Issue(2)：270-279,10.DOI:10.3969/j.issn.1006-2157.2025.02.017
富血小板血浆注射联合温针灸治疗膝骨关节炎寒湿痹阻证的临床研究
Platelet-rich plasma injection combined with warm acupuncture and moxibustion for treating patients with knee osteoarthritis and cold dampness obstruction syndrome
摘要
Abstract
Objective To determine the clinical efficacy of platelet-rich plasma(PRP)injection combined with warm acupuncture and moxibustion for treating patients with knee osteoarthritis and cold dampness obstruction syndrome.Methods One hundred and twenty-eight patients with knee osteoarthritis and cold dampness obstruction syndrome who visited the Rehabilitation Department and Orthopedics Department of the Second Affiliated Hospital of Anhui University of Chinese Medicine from January 2023 to March 2024 and who met the inclusion and exclusion criteria were randomly divided into an experimental(n=64)and control group(n=64)using the random number table method.The experimental group was treated with PRP injection combined with warm acupuncture and moxibustion,whereas the control group was treated with normal saline injection combined with warm acupuncture and moxibustion treatment.PRP and normal saline injections were administered once every two weeks,a total of four times.Patients were treated with warm acupuncture and moxibustion once a day,six times a week,for four consecutive weeks.The Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Traditional Chinese Medicine(TCM)syndrome,visual analog scale(VAS),and Lysholm scores were determined before treatment,at week 4 and week 8 of treatment,and week 16 of follow-up.Serum interleukin-6(IL-6),matrix metalloproteinase-3(MMP-3),tumor necrosis factor-α(TNF-α),osteoprotegerin(OPG),bone gla protein(BGP),and cartilage oligomeric matrix protein(COMP)levels were compared between the two groups before and after 8 weeks of treatment.The clinical efficacy and safety indicators between the two groups were also compared.Results There was no statistical difference in baseline data such as gender,age,disease duration,and body mass index between the two groups of patients.Compared with before treatment,both groups showed decreased WOMAC total and subscale,TCM syndrome total score and symptom scores,and VAS scores,and an increase in Lysholm scores at 4,8,and 16 weeks after treatment.After treatment,serum IL-6,MMP-3,TNF-α,and COMP levels decreased,whereas serum OPG and BGP levels increased(P<0.05).Compared with the control group,patients in the experimental group showed decreased WOMAC total and subscale,TCM syndrome total score and symptom scores,and VAS scores,and an increase in Lysholm score at 4,8,and 16 weeks after treatment.Compared with the control group,patients in the experimental group showed decreased serum IL-6,MMP-3,TNF-α,and COMP levels and an increase in serum OPG and BPG levels after treatment(P<0.05).The total effective rate of the experimental group was 91.94%,higher than that of the control group(81.97%;P<0.05).Conclusion PRP injection combined with warm acupuncture and moxibustion can improve various TCM symptoms,improve knee joint function and bone metabolism,and reduce inflammation in patients with knee osteoarthritis and cold dampness obstruction syndrome.关键词
膝骨关节炎/富血小板血浆/西安大略和麦克马斯特大学骨关节炎指数评分/炎症因子/骨代谢Key words
knee osteoarthritis/platelet-rich plasma/Western Ontario and McMaster Universities Osteoarthritis Index score/inflammatory factor/bone metabolism分类
医药卫生引用本文复制引用
尚祥,王飞,杨琪琪,姜天鑫,张芬,吴三兵,杨永晖,李飞..富血小板血浆注射联合温针灸治疗膝骨关节炎寒湿痹阻证的临床研究[J].北京中医药大学学报,2025,48(2):270-279,10.基金项目
安徽省自然科学基金面上项目(No.2308085MH297) （No.2308085MH297）
安徽省级区域中医康复中心建设项目(皖中医药服务秘[2022]34 号) （皖中医药服务秘[2022]34 号）
安徽省级临床重点专科建设项目(皖卫传[2022]297号) Natural Science Foundation of Anhui Province(No.2308085MH297) （皖卫传[2022]297号）
