摘要
Abstract
Objective:To analyze the medical value of early restrictive fluid resuscitation therapy in patients with severe pneumonia combined with septic shock.Methods:A total of 100 patients with severe pneumonia combined with septic shock admitted to Changzhou Geriatric Hospital affiliated to Soochow University from January 2023 to December 2023 were included in the study.The patients were divided into two groups according to the randomized sampling method,with 50 cases in each group.One group received routine treatment(the control group),while the other group received early restrictive fluid resuscitation(the observation group).Inflammatory factors,coagulation function,and the time of recovery from shock were compared between the two groups before and after treatment.Results:After treatment,levels of inflammatory factors such as IL-4,IL-12,and gamma interferon were lower than before treatment,and the observation group was lower than the control group after treatment(P＜0.05),indicating that inflammatory response of patients in the observation group was improved more significantly.After treatment,the activated partial thromboplastin time and prothrombin time increased,while the fibrinogen and thrombin time decreased in both groups,and the improvement in the observation group was better than that in the control group(P＜0.05),indicating that the endogenous coagulation function recovery in the observation group was better than that in the control group.The time of recovery shock,the total amount of fluid supplementation,the time of mechanical ventilation,and the time of vasoactive drug use in the observation group were lower than those of control group(P＜0.05).Glasgow prognosis score(GOS)and Glasgow coma score(GCS)before treatment had no statistical difference between the two groups(P＞0.05),and the improvement of the two indexes in the observation group was better than that in the control group after treatment(P＜0.05),indicating that the improvement of consciousness and prognosis in the observation group were better than those in the control group.Conclusions:For severe pneumonia complicated with septic shock,early restrictive fluid resuscitation based ob conventional treatment can rapidly reduce the levels of inflammatory factors in patients,regulate the coagulation function,shorten the time for shock improvement,and help patients recover.关键词
液体复苏,早期,限制性/肺炎,重症/休克,感染性/凝血功能/炎性因子Key words
Early restrictive fluid resuscitation/Severe pneumonia/Septic shock/Coagulation function/Inflammatory factor分类
临床医学
