吉林医药学院学报2025，Vol.46Issue(1)：28-32,5.
幽门螺杆菌抗体分型检测对疾病评估的价值
Value of Helicobacter Pylori Antibody Typing in Disease Assessment
摘要
Abstract
Objective To explore the value of Helicobacter pylori(Hp)antibody typing in the assessment of liver and anemia status.Meth-ods A total of 154 healthy people in the Fifth People's Hospital of Huai'an were selected as the research objects to detect Hp antibody,blood routine and routine biochemical indexes,and analyze the correlation between Hp antibody and each detection index.Results There was no significant correlation with sex,age and body mass index between negative and positive Hp antibody group(P>0.05).The indexes of white blood cell count,neutrophil count,lymphocyte count(LYM#),platelet count and albumin-globulin ratio(A/G)with posi-tive Hp antibody group(n=94)were significantly lower than the negative Hp antibody group(n=60),and the indexes of the total bilirubin,direct bilirubin,and globulin were contrary(P<0.05).The coefficient variation of red blood cell volume distribution width of Hp type Ⅰ in-fection was higher than the type Ⅱ infection(P<0.05).The comparison of different groups of Hp antibody type Ⅰ showed that the mean cor-puscular volume(MCV)、mean corpuscular hemoglobin(MCH)and standard deviation of red blood cell volume distribution width(RDW-SD)of Urease antibodies(Ure Ab)(+)and Vacuotoxin associated protein A antibody,(VacA Ab)(+)groups were higher than Ure Ab(+)and VacA Ab(-)groups,and the LYM#was lower(P<0.05).Similarly,MCV,MCH and RDW-SD with Ure Ab(+),Cytotoxin associated protein A antibody,(CagA Ab)(+),VacA Ab(+)were higher than Ure Ab(+),CagA Ab(+),VacA Ab(-)group,yet the ratio of alanine aminotransferase with aspartate aminotransferase was decrease(P<0.05).Conclusion Hp antibody type can evaluate the liver and ane-mia status of the body,and has a guiding role in the evaluation and treatment of the disease.关键词
幽门螺杆菌/血常规/生化指标/细胞毒素相关蛋白A抗体/空泡毒素相关蛋白A抗体Key words
Helicobacter pylori/blood routine/biochemistry indexes/cytotoxin associated protein A antibody/vacuotoxin associated pro-tein A antibody分类
临床医学引用本文复制引用
熊雪松,张玉东,李雨婷,顾万娟,王亮,李芬..幽门螺杆菌抗体分型检测对疾病评估的价值[J].吉林医药学院学报,2025,46(1):28-32,5.基金项目
广东省基础与应用基础研究基金资助(2022A1515220023) （2022A1515220023）
淮安市卫健委自然科学基金项目(HABL-202258) （HABL-202258）
