吉林医药学院学报2025，Vol.46Issue(1)：33-37,5.
替吉奥维持治疗一线化疗后无疾病进展晚期胃癌的PSM分析
PSM Analysis of Advanced Gastric Cancer without Disease Progression after First-Line Chemotherapy with Teggio Maintenance Therapy
摘要
Abstract
Objective To analyze the efficacy and safety of Teggio maintenance in the treatment of advanced gastric cancer without dis-ease progression after first-line chemotherapy by propensity score matching(PSM).Methods Patients with advanced gastric cancer ad-mitted from January 2021 to December 2022 were selected.PSM nearest matching method was used to select 44 patients in each group(maintenance treatment after chemotherapy cycle)and control group(follow-up observation after chemotherapy cycle)with a ratio of 1∶1.The clinical efficacy,progression-free survival(PFS),tumor markers and adverse reactions were compared between the two groups.Results The median follow-up time was 22.9 months as of March 20,2024.The median PFS of the Teggio group was 11.5 months(95%CI:10.961～12.039)and that of the control group was 8.3 months(95%CI:8.011～8.589),the PFS in the Teggio group was higher than that in the control group(χ2=10.125,P=0.001).At 3-month follow-up,the levels of CEA,CA199,CA125,and CA724 in the Tegio group were lower than at baseline and in the control group.The proportion of thrombocytopenia and hand-foot syndrome in the Teggio group was higher than that in the control group during follow-up,and adverse events were effectively controlled and alleviated by symp-tom treatment or dose reduction of Teggio.Conclusion Teggio maintenance therapy can inhibit tumor invasion and prolong the progression-free survival of patients with advanced gastric cancer after first-line chemotherapy.During treatment,attention should be paid to the adverse reactions of patients and timely symptomatic treatment.关键词
胃癌/维持治疗/无进展生存期/替吉奥/化疗Key words
gastric cancer/maintenance therapy/progression-free survival/Teggio/chemotherapy分类
临床医学引用本文复制引用
陆元元,丁文评..替吉奥维持治疗一线化疗后无疾病进展晚期胃癌的PSM分析[J].吉林医药学院学报,2025,46(1):33-37,5.基金项目
安徽省教育厅科学研究项目(KJ2021A0827) （KJ2021A0827）
