摘要
Abstract
Objective:The number of middle-aged and elderly patients with type 2 diabetes mellitus(T2DM)is continuously increasing.Diabetic retinopathy(DR),one of the common and devastating complications of diabetes mellitus(DM),is also on the rise.Insulin resistance(IR)is closely related to DR,and the triglyceride-glucose(TyG)index is a reliable indicator for evaluating IR;however,its relationship with DR remains unclear.The study aims to investigate the association between the TyG index and the risk of DR in middle-aged and elderly T2DM patients.
Methods:A total of 730 T2DM patients hospitalized in the Department of Endocrinology of the First People's Hospital of Hefei from 2010 to 2023 were selected as study subjects.According to the quartiles of the TyG index,the patients were divided into 4 groups:The lowest quartile(Q1)group(TyG index≤8.85,n=184),the second quartile(Q2)group(TyG index>8.85 to 9.24,n=183),the third quartile(Q3)group(TyG index>9.24 to 9.68,n=182),and the highest quartile(Q4)group(TyG index>9.68,n=181).Univariate and multivariate Logistic regression analyses were used to explore the risk factors for DR in T2DM patients.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of the TyG index for DR in middle-aged and elderly T2DM patients.
Results:Univariate analysis indicated that disease duration,systolic blood pressure,serum triglyceride(TG),total cholesterol(TC),glycosylated hemoglobin(HbA1C),fasting plasma glucose(FPG),and the TyG index were all factors affecting DR(all P<0.05).Multivariate Logistic regression analysis demonstrated that a high TyG index was an independent risk factor for DR in middle-aged and elderly T2DM patients(P<0.05).ROC curve analysis revealed that the areas under the curve(AUC)for TyG index,TG,FPG,and HbA1C in predicting DR were 0.731,0.673,0.669,and 0.611,respectively.
Conclusion:The TyG index is significantly associated with the risk of DR in the middle-aged and elderly T2DM patients.It is recommended that the TyG index is evaluated at the initial diagnosis of DM and used as an early warning indicator for risk stratification in these patients.关键词
2型糖尿病/甘油三酯-葡萄糖指数/糖尿病视网膜病变/胰岛素抵抗/中老年人Key words
type 2 diabetes mellitus/triacylglycerol-glucose index/diabetic retinopathy/insulin resistance/middle-aged and elderly
