临床与病理杂志2024，Vol.44Issue(10)：1430-1439,10.DOI:10.11817/j.issn.2095-6959.2024.240759
患者来源癌症模型在甲状腺癌中的应用
Application of patient-derived models of cancer in thyroid cancer
摘要
Abstract
To overcome the limitations of in vitro cancer cell lines or cell derived xenograft(CDX)models,and to produce more reliable preclinical results,researchers have introduced patient-derived models of cancer(PDMC).Currently,PDMC mainly include two types:patient-derived xenograft(PDX)model and patient-derived organoids(PDO)model.Both PDX and PDO models have distinct characteristics and advantages.Due to the high consistency between PDMC and the characteristics of patient's tumors,these models have been widely adopted in various cancer research areas,particularly in the development and screening of anti-cancer drugs,as well as in personalized medicine and precision medicine,showing significant research progress.In recent years,the incidence of thyroid cancer in China has been steadily increasing,becoming an urgent public health challenge.Therefore,establishing comprehensive and effective preclinical thyroid cancer models to explore novel therapeutic drugs and treatment methods is especially urgent and important.With continuous technological advancements and optimization of models,PDMC are expected to provide a solid experimental foundation and individualized treatment strategies for precision therapy in thyroid cancer and other tumors.关键词
甲状腺癌/患者来源癌症模型/患者来源异种移植模型/患者来源类器官模型/肿瘤类器官来源的异种移植模型Key words
thyroid cancer/patient-derived models of cancer/patient-derived xenograft model/patient-derived organoids model/patient-derived organoids xenograft model引用本文复制引用
黄文,危靖怡,袁梦晖,袁鹏..患者来源癌症模型在甲状腺癌中的应用[J].临床与病理杂志,2024,44(10):1430-1439,10.基金项目
空军军医大学临床研究项目(2023LC2325).This work was supported by the Clinical Research Project of Air Force Medical University,China(2023LC2325). （2023LC2325）
