临床与病理杂志2024，Vol.44Issue(10)：1448-1457,10.DOI:10.11817/j.issn.2095-6959.2024.230188
载脂蛋白E基因多态性的病理生理学功能及分子机制
Pathophysiological functions and molecular mechanisms of apolipoprotein E gene polymorphism
摘要
Abstract
Apolipoprotein E(ApoE),a multifunctional protein,plays a crucial role in lipoprotein metabolism.Different ApoE genotypes exhibit varying affinities for lipoproteins,and its polymorphism can affect lipoprotein levels.Numerous studies have confirmed that ApoE is involved in lipid metabolism,cardiovascular and cerebrovascular diseases,Alzheimer's disease,chronic kidney disease,diabetes,multiple sclerosis,and various cancers.Different genotypes may display distinct or even opposite functions,and serum ApoE levels tend to change progressively with the development of these diseases.Investigating the association and roles of ApoE gene polymorphism and serum levels in disease occurrence and progression can provide further theoretical evidence for early detection,timely intervention,dynamic monitoring,and precision treatment.关键词
载脂蛋白E/基因多态性/脂代谢/心脑血管疾病/阿尔茨海默病/糖尿病/肿瘤Key words
ApoE/genetic polymorphism/lipid metabolism/cardiovascular and cerebrovascular diseases/Alzheimer's disease/diabetes/tumors引用本文复制引用
王玥,阿合拉·哈力别克,司文喆..载脂蛋白E基因多态性的病理生理学功能及分子机制[J].临床与病理杂志,2024,44(10):1448-1457,10.基金项目
国家自然科学基金(82303063) （82303063）
北京市科技新星计划(20220484090,20230484442) （20220484090,20230484442）
北京市自然科学基金(7232206) （7232206）
北京市卫生健康委员会优促计划赋能项目(YC202301QX0087).This work was supported by the National Natural Science Foundation(82303063),Beijing Nova Program(20220484090,20230484442),Beijing Natural Science Foundation(7232206),Beijing Municipal Health Commission Excellent Promotion Plan Empowerment Project(YC202301QX0087),China. （YC202301QX0087）
