神经损伤与功能重建2025，Vol.20Issue(2)：93-96,4.DOI:10.16780/j.cnki.sjssgncj.20240936
自噬调控在精神分裂症中的研究进展
Research Progress of Autophagy Regulation in Schizophrenia
摘要
Abstract
Schizophrenia is a common and severe mental disorder with unknown mechanisms.In recent years,a large number of studies on the correlation between autophagy and schizophrenia have suggested that autophagy may be part of the pathophysiological process of schizophrenia.Moreover,treatments such as medication,phys-ics,and psychotherapy may alleviate psychotic symptoms by regulating autophagy,making autophagy regulation a new direction for the treatment of schizophrenia.This paper reviews the relationship between autophagy and the pathogenesis of schizophrenia,as well as advancements in autophagy-related treatments,providing new ideas for the diagnosis and treatment exploration of schizophrenia.关键词
自噬/精神分裂症/发病机制/治疗Key words
autophagy/schizophrenia/pathogenesis/therapy分类
临床医学引用本文复制引用
熊樱,王惠玲..自噬调控在精神分裂症中的研究进展[J].神经损伤与功能重建,2025,20(2):93-96,4.基金项目
湖北省重点研发计划项目(基于多类型生物标志物和脑影像融合分析早期预测重性精神疾病神经认知障碍研究,No.2023BCB133) （基于多类型生物标志物和脑影像融合分析早期预测重性精神疾病神经认知障碍研究,No.2023BCB133）
国家自然科学基金项目(TRPV1/SIRT3介导线粒体损伤在精神分裂症认知功能障碍中的作用及机制研究,No.82471523) （TRPV1/SIRT3介导线粒体损伤在精神分裂症认知功能障碍中的作用及机制研究,No.82471523）
武汉大学人民医院交叉创新人才项目[氢化钯纳米粒子(PdH@CM)靶向清除小胶质细胞ROS改善精神分裂症认知功能损伤的机制研究,No.JCRCFZ-2022-03] （PdH@CM）
