神经损伤与功能重建2025，Vol.20Issue(2)：97-101,5.DOI:10.16780/j.cnki.sjssgncj.20241124
细胞自噬在神经退行性疾病中作用的研究进展
Research Progress on the Role of Autophagy in Neurodegenerative Diseases
摘要
Abstract
The pathological features of neurodegenerative diseases mainly include the accumulation and deposi-tion of abnormally misfolded proteins or peptides.Autophagy can clear intracellular aggregated proteins and dys-functional organelles,making it an important target for delaying the progression of neurodegenerative diseases.Impairments in the production or maturation process of autophagosomes can promote the development and pro-gression of neurodegenerative diseases.A thorough understanding of the signal transduction pathways regulating autophagy is crucial for devising treatment strategies for related diseases.This paper mainly introduces the impor-tant role of autophagy in neurodegenerative diseases and its associated molecular mechanisms.关键词
自噬/信号通路/神经退行性疾病Key words
autophagy/signal transduction pathways/neurodegenerative diseases分类
临床医学引用本文复制引用
孙铭涵,王玥,赵丽..细胞自噬在神经退行性疾病中作用的研究进展[J].神经损伤与功能重建,2025,20(2):97-101,5.基金项目
北京市自然科学基金面上项目(TREM2介导小胶质细胞自噬减轻1型糖尿病认知功能障碍的作用及机制,No.7232003) （TREM2介导小胶质细胞自噬减轻1型糖尿病认知功能障碍的作用及机制,No.7232003）
国家自然科学基金面上项目(TREM2 调 控DAM在1型糖尿病认知功能障碍中作用及其机制,No.82071539) （TREM2 调 控DAM在1型糖尿病认知功能障碍中作用及其机制,No.82071539）
