赣南医科大学学报2025，Vol.45Issue(1)：11-17,7.DOI:10.3969/j.issn.1001-5779.2025.01.002
液体活检技术在乳腺癌领域中的研究及应用现状
Research and application of liquid biopsy in breast cancer
摘要
Abstract
Liquid biopsy,as an emerging non-invasive biopsy technique,is widely used in the field of tumor diagnosis and treatment.It obtains tumor tissue derived biomarkers by detecting body fluids such as blood and urine,and brings about a revolution in precision medicine for tumors due to its simple operation,good reproducibility,and non-invasive character-istics.Breast cancer is a high incidence of female malignant tumor,its early diagnosis and precise treatment are crucial to improve the prognosis of patients.In this context,the application value of liquid biopsy technology in the field of breast cancer has attracted much attention.Based on the recent research literature both domestically and internationally,this article discusses the detection technology of liquid biopsy and its application in breast cancer.The results of literature re-view showed that although the detection principles and technical characteristics of circulating tumor cells,circulating tu-mor DNA,exosomes,tumor associated microparticles and tumor-educated platelets were different,these liquid biopsy indicators provided powerful support in the early screening and clinical diagnosis of breast cancer,tumor staging and prognosis evaluation,and treatment response evaluation.These results indicate that liquid biopsy technology has a broad application prospect in the field of breast cancer,and technical optimization and integration still need to be improved in the future to promote its extensive and standardized application in the clinical diagnosis and treatment of breast cancer.关键词
液体活检/乳腺癌/循环肿瘤细胞/循环肿瘤DNA/外泌体Key words
Liquid biopsy/Breast cancer/Circulating tumor cells/Circulating tumor DNA/Exosomes分类
临床医学引用本文复制引用
刘梦莹,蔡浩,何明,罗芸,郭有..液体活检技术在乳腺癌领域中的研究及应用现状[J].赣南医科大学学报,2025,45(1):11-17,7.基金项目
国家自然科学基金资助项目(81903186) （81903186）
江西省重点研发计划项目(20203BBGL73202) （20203BBGL73202）
江西省教育厅科学技术研究项目(GJJ211544,GJJ211545,GJJ211549) （GJJ211544,GJJ211545,GJJ211549）
