中国耳鼻咽喉头颈外科2025，Vol.32Issue(1)：1-7,7.DOI:10.16066/j.1672-7002.2025.01.001
鼻咽癌组织驱动蛋白超家族18B、20A与上皮间质转化标志物及临床病理特征和预后的关系
The relationship between kinesin superfamily 18B,20A and epithelial-mesenchymal transition markers,clinicopathological features and prognosis in nasopharyngeal carcinoma
摘要
Abstract
OBJECTIVE To investigate the relationship between kinesin superfamily(KIF)18B,20A and epithelial-mesenchymal transition(EMT)markers,clinicopathological features and prognosis in nasopharyngeal carcinoma.METHODS 116 cases of nasopharyngeal biopsy tumor tissues diagnosed as nasopharyngeal carcinoma in Department of Otolaryngology,Yulin Traditional Chinese Medicine Hospital from July 2017 to May 2019 were selected,nasal mucosa biopsy tissues of 116 chronic nasopharyngitis patients were used as control,the expression of KIF18B,KIF20A,and EMT markers epithelial calreticulin(E-cadherin),vimentin,twist in nasopharyngeal carcinoma tissues and nasopharyngeal chronic mucositis tissues were compared.The relationship between KIF18B,KIF20A expression and EMT marker expression and clinicopathological features in nasopharyngeal carcinoma tissues were analyzed.5 years after follow-up,the relationship between KIF18B,KIF20A expression and the prognosis of nasopharyngeal carcinoma patients were analyzed by the Kaplan-Meier method and multivariate Cox regression analysis.RESULTS The positive expression rates of KIF18B,KIF20A,Vimentin and Twist in nasopharyngeal carcinoma tissues were 55.17％,42.24％,20.69％,and 26.72％respectively,which were higher than 13.79％,9.48％,4.31％,and 5.17％in nasopharyngeal chronic mucosal inflammation tissues;The positive expression rate of E-cadherin in nasopharyngeal carcinoma tissues was 68.10％,which was lower than 91.38％in nasopharyngeal chronic mucosal inflammation tissues(P<0.05).KIF18B and KIF20A were negatively correlated with E-cadherin expression(rs=-0.439,-0.432,P<0.05),KIF18B,KIF20A were positively correlated with Vimentin(rs=0.418,0.456,P<0.05)and Twist(rs=0.427,0.427,P<0.05).The KIF18B and KIF20A positive expression rates in patients with low differentiation,lymph node metastasis,TNM stage Ⅲ-Ⅵa,clinical efficacy stable disease(SD)/progressive disease(PD)were higher than those in patients with high differentiation,no lymph node metastasis,stage Ⅰ-Ⅱ,and complete response(CR)/partial response(PR)(P<0.05).4 patients were lost to 5 years after follow-up,the success rate of follow-up was 96.55％(112/116),31 patients died,and the 5-year overall survival rate was 72.32％(81/112).The 5-year cumulative survival rate in KIF18B and KIF20A positive expression nasopharyngeal carcinoma patients were lower than those in KIF18B and KIF20A negative expression nasopharyngeal carcinoma patients(P<0.05).TNM stage Ⅲ-Ⅵa(HR=1.154,95％CI:1.018-1.308),clinical efficacy SD/PD(HR=1.287,95％CI:1.132-1.654),KIF18B(HR=1.823,95％CI:1.332-2.493)and positive expression of KIF20A(HR=2.110,95％CI:1.460-3.051)were independent risk factors affecting the prognosis of nasopharyngeal carcinoma patients(P<0.05).CONCLUSION KIF18B and KIF20A are abnormally highly expressed in nasopharyngeal carcinoma tissues,the positive expression of the two are closely related to EMT,tumor malignant progression and prognosis,and KIF18B,KIF20A positive expression patients have shorter survival time.关键词
鼻咽肿瘤/预后/驱动蛋白超家族18B/驱动蛋白超家族20A/上皮间质转化/临床病理特征Key words
Nasopharyngeal Neoplasms/Prognosis/kinesin superfamily 18B/kinesin superfamily 20A/epithelial-mesenchymal transition/clinicopathological features引用本文复制引用
白芸芸,贾乐,陈福权..鼻咽癌组织驱动蛋白超家族18B、20A与上皮间质转化标志物及临床病理特征和预后的关系[J].中国耳鼻咽喉头颈外科,2025,32(1):1-7,7.基金项目
陕西省卫生健康科研项目(2021D015) （2021D015）
