中国耳鼻咽喉头颈外科2025，Vol.32Issue(1)：8-12,5.DOI:10.16066/j.1672-7002.2025.01.002
鼻咽癌放疗后患者内毒素和可溶性白细胞介素2受体水平与化脓性中耳炎发生的相关性
Correlation between endotoxin and sIL-2R levels and the occurrence of suppurative otitis media in patients with nasopharyngeal carcinoma after radiotherapy
摘要
Abstract
OBJECTIVE To investigate the relationship between the expression level of endotoxin and soluble interleukin-2 receptor(sIL-2R)and the occurrence of suppurative otitis media in patients with nasopharyngeal carcinoma after radiotherapy.METHODS Seventy-nine nasopharyngeal cancer patients who received radiotherapy in Nanyang Downtown Hospital between January 2022 and July 2023 were selected as the study subjects,and they were followed up for a period of 1 year,and then grouped according to the occurrence of suppurative otitis media during the follow-up period,i.e.,21 cases in the occurringgroup and 58 cases in the non-occurring group,and the baseline data of patients in the two groups were compared,and the levels of endotoxin and sIL-2R were detected at the end of radiotherapy and analyze the relationship between endotoxin,sIL-2R and the occurrence of purulent otitis media after radiotherapy for nasopharyngeal carcinoma.RESULTS A total of 21 cases(26.58%)of 79 nasopharyngeal carcinoma patients developed suppurative otitis media after radiotherapy.Compared with the non-occurrence group,the radiotherapy time,endotoxin,sIL-2R,TNM stage Ⅲ,Eustachian tube involvement,nasal cavity structural abnormality,inflammatory reaction,and palatal sail tensor atrophy degree≥30%were high in the occurrence group,and the difference was statistically significant(all P<0.05).The results of logistic multifactorial analysis showed that inflammatory reaction,endotoxin,abnormal nasal structure,TNM stage(Ⅲ),sIL-2R,Eustachian tube involvement,duration of radiotherapy,and degree of atrophy of palatofacial tensor atrophy≥30%were all risk factors for suppurative otitis media.The results of Spearman's rank correlation analysis showed that endotoxin and sIL-2R were positively correlated with the occurrence of septic otitis media(r=0.493,0.516,P<0.001).Analysis using the ROC curve showed that:endotoxin:AUC value:0.657,sensitivity:61.90%,specificity:72.41%,accuracy:69.62%,95%CI=0.523-0.791;sIL-2R:AUC value:0.697,sensitivity:71.43%,specificity:67.24%,accuracy:68.35%,95%CI=0.566-0.829;combined test:AUC value:0.804,sensitivity:95.24%,specificity:65.52%,accuracy:73.42%,95%CI=0.705-0.903,the best value of the two combined tests.CONCLUSION The elevated levels of endotoxin and sIL-2R in patients with nasopharyngeal carcinoma after radiotherapy may be associated with suppurative otitis media.关键词
鼻咽肿瘤/中耳炎,化脓性/内毒素/可溶性白细胞介素2受体/放疗Key words
Nasopharyngeal Neoplasms/Otitis Media,Suppurative/Endotoxins/soluble interleukin-2 receptor/radiotherapy引用本文复制引用
魏璐璐,吉文伟,尹中普,范栩嫚,陈子涵..鼻咽癌放疗后患者内毒素和可溶性白细胞介素2受体水平与化脓性中耳炎发生的相关性[J].中国耳鼻咽喉头颈外科,2025,32(1):8-12,5.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20191456) （联合共建）
