广州医药2025，Vol.56Issue(2)：197-202,246,7.DOI:10.20223/j.cnki.1000-8535.2025.02.009
重症烧伤患者血培养念珠菌阳性的病原学特征
Pathogenic characteristics of Candida positive blood culture in severe burn patients
赖艳榕 1沈仲华 2朱伟聪 3曹颖仪 1何雅军1
作者信息
- 1. 广州市红十字会医院检验科(广东 广州 510220)
- 2. 广州市红十字会医院院感管理科(广东 广州 510220)
- 3. 广州市红十字会医院创伤外科研究所(广东 广州 510220)
- 折叠
摘要
Abstract
Objective To retrospective analyze the clinical distribution of Candida species detected in blood cultures of patients with severe burns and to investigate the etiological characteristics of Candida bloodstream infections in these patients.Methods A total of 1148 blood culture specimens were collected from patients with severe burns hospitalized at an institution between 2012 and 2023.Patients data with Candida bloodstream infections isolated from 1 148 blood culture specimens were analyzed,including mortality rates,species distribution,Candida culture results from other simultaneously collected specimen types,and the timing and seasonal distribution of Candida bloodstream infections,the use of antibiotics and resistance to commonly-used antifungal drugs.Results A total of 1 148 blood culture samples,77 fungi were separated,resulting in a positive rate of 6.71%.Among the 27 patients with Candida infections,13 cases(48.15%)were caused by Candida parapsilosis and 8 cases(29.63%)by Candida albicans.Candida was isolated from both blood and intravenous catheter cultures in 22 cases,with a positivity rate of 81.48%.Candida was isolated from both blood and wound secretion cultures in 10 cases(positivity rate of 37.04%),and 4 cases from blood,intravenous catheter and wound secretion cultures(positivity rate of 14.81%).The detection rate of Candida from intravenous catheters was higher than that from other specimen types.Candida bloodstream infections were most commonly observed during the 2nd and 3rd week after admission,with a seasonal peak in spring and summer.The susceptibility rates of Candida parapsilosis、Candida albicans and Candida tropicalis to fluconazole were 83.33%、87.50%and 75.00%,respectively.Conclusions The detection rate of Candida parapsilosis in bloodstream infections among patients with severe burns was the highest.These infections predominantly occur during the spring and summer and in the 2nd and 3rd week post-admission.The presence of intravenous catheters significantly contributes to Candida infections.The Candida in the hospital has high sensitivity to antifungal drugs.关键词
重度烧伤/念珠菌感染/血培养/静脉导管/伤口分泌物Key words
severe burns/Candidainfections/blood culture/intravenous catheters/wound secretion引用本文复制引用
赖艳榕,沈仲华,朱伟聪,曹颖仪,何雅军..重症烧伤患者血培养念珠菌阳性的病原学特征[J].广州医药,2025,56(2):197-202,246,7.
