摘要
Abstract
Objective To investigate the prognostic value of serum syndecan-1(SCD-1)and soluble vascular endothelial growth factor receptor-2(sVEGFR-2)expression levels in elderly patients with chronic heart failure.Methods A total of 110 elderly patients with chronic heart failure admitted to our hospital were selected,with a time interval of January 2023 to March 2024.Serum SCD-1 and sVEGFR-2 levels were detected and follow-up investigations were conducted to understand their re hospitalization and cardiogenic death due to heart failure.Multiple logistic regression analysis was used to explore the prognostic factors affecting elderly patients with chronic heart failure.Results According to logistic retrospective analysis,heart function grading(OR=3.433,95%CI:0.934-6.431),elevated B-type brain natriuretic peptide(OR=2.462,95%CI:0.861-4.765),elevated serum SCD-1(OR=3.795,95%CI:0.972-6.894),and elevated serum sVEGFR-2(OR=3.842,95%CI:0.942-6.912)were important factors affecting the poor prognosis of elderly patients with chronic heart failure,with differences P＜0.05.The area under the curve of combined serum SCD-1 and sVEGFR-2 was 0.962,and the area under the curve of B-type brain peptide sodium was 0.844,which was significantly higher than that of a single SCD-1 curve of 0.658 and sVEGFR-2 curve of 0.712,with a difference of P＜0.05.Conclusions Research has confirmed that the prognosis of elderly patients with chronic heart failure is not satisfied,and their serum SCD-1 and sVEGFR-2 monitoring levels are abnormally elevated,which is related to the poor prognosis of elderly patients with chronic heart failure.It can be regarded as the main biomarker for defining the prognosis of elderly patients with chronic heart failure.关键词
多配体蛋白聚糖-1/可溶性血管内皮生长因子受体-2/慢性心力衰竭/预后评估价值Key words
syndecan-1/soluble vascular endothelial growth factor receptor-2/chronic heart failure/prognostic value
