法医学杂志2024，Vol.40Issue(6)：550-556,7.DOI:10.12116/j.issn.1004-5619.2024.340103
新型合成卡西酮类物质CMMP的检验
Identification of a Novel Synthetic Cathinone CMMP
摘要
Abstract
Objective To establish a method to identify an unknown substance based on the combined use of gas chromatography-quadrupole time-of-flight mass spectrometry(GC-QTOF-MS),ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q/Orbitrap HRMS)and nuclear magnetic resonance(NMR)techniques.Methods The unknown substance was dissolved in methanol and was detected by GC-QTOF-MS and UPLC-Q/Orbitrap HRMS,and was dissolved in methanol-d4 to be detected by NMR.Results The main characteristics ion peaks of components with retention time of 9.67 min in GC-QTOF-MS measured were 84.080 8,110.999 7,128.107 0(base peak),138.994 7,etc.The protonated molecular ion peak m/z in UPLC-Q/Orbitrap HRMS was 268.109 3.It was inferred that the unknown substance was an analog of the syn-thetic cathinone substance 2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one(MTMP)by comparing the mass spectrum information and molecular structure of MTMP.NMR analysis confirmed it as a novel N-morpholine substituted synthetic cathinone substance 1-(4-chlorophenyl)-2-methyl-2-morpholinopropan-1-one(CMMP).Conclusion The method established in this study can be used for structural confirmation of CMMP.关键词
法医学/毒物分析/新精神活性物质/合成卡西酮类/2-甲基-1-(4-甲硫基苯基)-2-吗啉基丙-1-酮(MTMP)/1-(4-氯苯基)-2-甲基-2-吗啉基丙-1-酮(CMMP)/高分辨质谱/N-吗啉取代分类
医药卫生引用本文复制引用
何思阳,邓乾亚,郑水庆,倪春芳,孙文娟,曹芳琦,梁晨,龚飞君..新型合成卡西酮类物质CMMP的检验[J].法医学杂志,2024,40(6):550-556,7.基金项目
公安部科技计划项目(2023YY12) （2023YY12）
上海市2021年度"科技创新行动计划"社会发展科技攻关定向项目(21dz1200301,21dz1200303) （21dz1200301,21dz1200303）
上海市公安局科学技术发展基金资助项目(2022012) （2022012）
