口腔颌面外科杂志2025，Vol.35Issue(1)：34-42,9.DOI:10.12439/kqhm.1005-4979.2025.01.006
GSDM蛋白家族在头颈部鳞状细胞癌中的表达及其对预后的影响
The expression of GSDM protein family in HNSCC and its impact on prognosis
摘要
Abstract
Objective:To investigate the expression of Gasdermin(GSDM)protein family in squamous cell carcinoma of head and neck(HNSCC)and its diagnostic and prognostic value.Methods:Based on UALCAN and other public databases,the differential expression of GSDM protein family in HNSCC and its correlation with poor prognosis of HNSCC patients were analyzed,and the correlation between GSDM protein family and immune cell infiltration was clarified.Results:Compared with normal tissues,GSDM protein family was significantly increased in HNSCC tissues,and it was closely correlated with longer overall survival(OS)and immune cell infiltration in HNSCC patients.The gene function of GSDM protein family in HNSCC was mainly concentrated in pyrodeath.The Kyoto Encyclopedin of Genes and Genomes(KEGG)pathway was mainly rich in human papilloma virus infection.The GSDM protein family had a certain mutation rate in HNSCC.Conclusion:Based on tumor bioinformatics analysis,the expression level of GSDM protein family in HNSCC tissues is different from that in normal tissues,and its expression level is correlated with immune cell inflitration and tumor prognosis,which can be used as a prognostic marker of HNSCC and a target for gene therapy.关键词
头颈部鳞状细胞癌/GSDM蛋白家族/预后/免疫细胞浸润Key words
head and neck squamous cell carcinoma/GSDM protein family/prognosis/immune cell infiltration分类
口腔医学引用本文复制引用
刘炜,尚多,武旭,周兴安,苏尼特,德乐黑巴特尔..GSDM蛋白家族在头颈部鳞状细胞癌中的表达及其对预后的影响[J].口腔颌面外科杂志,2025,35(1):34-42,9.基金项目
内蒙古医科大学联合项目(YKD2023LH032) （YKD2023LH032）
内蒙古自治区高等学校科学研究项目(NJZY21634) （NJZY21634）
内蒙古自治区自然科学基金项目(2024QN08053) （2024QN08053）
