口腔颌面外科杂志2025，Vol.35Issue(1)：59-62,4.DOI:10.12439/kqhm.1005-4979.2025.01.010
高尔基体应激反应在骨代谢中的研究进展
Research advances on Golgi stress response in bone metabolism
摘要
Abstract
During the growth,development,and injury repair processes of mammals,organelles undergo self-regulation through a series of complex regulatory mechanisms when subjected to interference from inside or outside,in order to maintain cellular homeostasis.This process is known as organelle stress response.The Golgi apparatus is a key organelle within the cell,not only participating in physiological activities such as the processing and modification of intracellular proteins,lipid metabolism,and vesicular transport,but also playing an important role in ion homeostasis and stress responses.Bone metabolism is an important and complex process for maintaining skeletal health,involving the coordinated action of various cells such as osteoblasts and osteoclasts.In this process,the stress response of the Golgi apparatus helps to maintain the intracellular homeostasis and physiological functions of bone cells.This article reviews the research progress on Golgi apparatus stress response,including its structure,function,triggering factors,signal transduction pathways,and its impact on the function of bone tissue cells,aiming to provide new insights for the treatment of bone diseases.关键词
高尔基体/细胞器/应激反应/糖基化/骨代谢Key words
Golgi apparatus/organelle/stress response/glycosylation/bone metabolism分类
口腔医学引用本文复制引用
牛萍萍,孙瑶..高尔基体应激反应在骨代谢中的研究进展[J].口腔颌面外科杂志,2025,35(1):59-62,4.基金项目
国家自然科学基金优秀青年基金(81822012) （81822012）
