护理学报2025，Vol.32Issue(4)：53-58,6.DOI:10.16460/j.issn1008-9969.2025.04.053
肝细胞癌伴低血糖症风险预测模型的构建与验证
Construction and verification of risk prediction model for hypoglycemia with hepatocellular carcinoma
摘要
Abstract
Objective To construct and validate a hypoglycemia risk prediction model in patients with primary hepatocellular carcinoma(HCC).Methods A total of 232 patients with primary HCC from April 2020 to June 2021 were involved and divided into hypoglycemia group(n=67)and non-hypoglycemia group(n=165)according to the occurrence of hypoglycemia.The risk factors were retrospectively analyzed and risk prediction model was established.ROC curve was used to verify the efficacy of the prediction model.Results The analysis revealed that Child-Pugh grade C(OR=9.050,95%CI 2.911-28.130,P<0.001)was a risk factor for hypoglycemia in patients with HCC;but glycated hemoglobin(OR=0.504,95%CI 0.325-0.780,P=0.002)was a protective factor.The regression model was:Y=2.317+0.056 Child-Pugh stage(B)+2.203 Child-Pugh stage(C)-0.686 HbA1c;The area of the ROC curve was 0.737(95%CI 0.660-0.814),with a sensitivity of 53.7%and specificity of 87.3%.Model validation showed that the area of the ROC curve was 0.827(95%CI 0.727-0.927),with a sensitivity of 55%and specificity of 81.8%,which suggests good prediction efficacy of the model.Conclusion The hypoglycemia risk prediction model in patients with HCC can help identify population with high risk of hypoglycemia and provide scientific basis for prospective nursing intervention for medical staff.关键词
肝细胞癌/低血糖/风险预测模型Key words
hepatocellular carcinoma/hypoglycemia/risk prediction model分类
临床医学引用本文复制引用
郑小静,严红虹,李慧景,陈思涓,陈秀梅..肝细胞癌伴低血糖症风险预测模型的构建与验证[J].护理学报,2025,32(4):53-58,6.基金项目
广东省医学科研基金(B2021269) （B2021269）
