四川精神卫生2025，Vol.38Issue(1)：28-33,6.DOI:10.11886/scjsws20240506002
首发和复发精神分裂症患者新型炎症指标水平与攻击性的关系
Relationship between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia
摘要
Abstract
Background Aggressive behavior in schizophrenic patients could result in legal disputes and public safety concerns.In patients with illness episodes of different numbers,there may exist differences in the association between levels of novel inflammatory indicators and aggressivity.Objective To investigate the differences in the correlation between levels of novel inflammatory indicators and aggressivity in patients with first-episode and recurrent schizophrenia,in order to search for inflammatory biomarkers to assess aggression level in schizophrenic patients.Methods A total of 168 schizophrenic patients were selected as subjects,who were hospitalized for acute disease onset in Chaohu Hospital of Anhui Medical University from October 2022 to April 2024 as well as met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders,fifth edition(DSM-5).Patients were divided into first-episode group(n=58)and recurrent group(n=110).Meanwhile,110 healthy controls from community who matched in age and gender with the patient group were recruited.All patients were evaluated with Modified Overt Aggression Scale(MOAS)and Positive and Negative Syndrome Scale(PANSS).All subjects went through examination of the levels of novel inflammatory indicators,including neutrophil/lymphocyte ratio(NLR),monocyte/lymphocyte ratio(MLR),platelet/lymphocyte ratio(PLR),neutrophil/high-density lipoprotein ratio(NHR),monocyte/high-density lipoprotein ratio(MHR)and platelet/high-density lipoprotein ratio(PHR).Spearman correlation analysis was adopted to investigate the correlation between levels of novel inflammatory indicators and the total score of MOAS in patients with first-episode and recurrent schizophrenia.Results The levels of NLR,MLR,PLR,NHR,MHR and PHR in first-episode group were higher than those in control group(adjusted P<0.01).The levels of NLR,MLR,NHR,MHR and PHR in recurrent group were higher than those in control group(adjusted P<0.01).No significant difference was observed in the comparison in the levels of six novel inflammatory indicators between first-episode group and recurrent group(adjusted P>0.05).Spearman correlation analysis showed,the MOAS total score of recurrent group was positively correlated with the levels of NLR,MLR and PLR(r=0.234,0.192,0.243,P<0.05).There was no statistical significance in the correlation between MOAS total score and levels of six novel inflammatory indicators in first-episode group(P>0.05).Conclusion Among patients with first-episode and recurrent schizophrenia,the correlation between levels of novel inflammatory indicators and aggressivity could differ.NLR,MLR and PLR might be the biomarkers for assessing aggression level in recurrent schizophrenic patients.关键词
精神分裂症/首发/复发/新型炎症指标/攻击性Key words
Schizophrenia/First-episode/Recurrent/Novel inflammatory indicators/Aggressivity分类
临床医学引用本文复制引用
崔迎奥,杨铖,田英汉,申晴晴,刘寰忠..首发和复发精神分裂症患者新型炎症指标水平与攻击性的关系[J].四川精神卫生,2025,38(1):28-33,6.基金项目
安徽省自然科学基金项目(项目名称:基于GSK-3β/NF-kB信号通路对氯氮平所致代谢综合征的机制研究,项目编号:2108085MH275) Anhui Provincial Natural Science Foundation(number,2108085MH275) （项目名称:基于GSK-3β/NF-kB信号通路对氯氮平所致代谢综合征的机制研究,项目编号:2108085MH275）
