肿瘤预防与治疗2025，Vol.38Issue(2)：162-170,9.DOI:10.3969/j.issn.1674-0904.2025.02.011
川东北地区40～69岁居民上消化道癌危险因素及其区域聚集关系分析
Risk Factors and Spatial Clustering of Upper Gastrointestinal Cancers in Residents Aged 40～69 in Northeastern Sichuan
摘要
Abstract
Objective:To analyze the onset,risk factors and spatial clustering of upper gastrointestinal cancers in northeastern Sichuan,providing evidence for prevention and control efforts.Methods:Data were collected from screening records in four counties(Langzhong,Nanbu,Xichong and Cangxi)from 2016 to 2023.A database was established using EpiData 3.1,and data analysis was performed using SAS 9.2.Univariate analysis was conducted using the 2 test,while multivariate logistic regression was employed to identify factors as-sociated with cancer and precancerous lesions.Spatial epidemiological methods were utilized,calculating relative risk and Moran's I values using R 4.3.3 to reveal high and low incidence areas at county and township levels.Results:A total of 65,620 individuals were surveyed,reporting 973 positive cases,with a detection rate of 1.48%.Detection rates for esopha-geal,cardia and gastric cancers were 1.18%,0.16%and 0.16%,respectively.Higher prevalence rates of upper gastroin-testinal cancers and precancerous lesions were observed among respondents from Langzhong County,male respondents,aged respondents,respondents with other marriage,primary school or below respondents,respondents having family number of 6 people and above,respondents with BMI<18.5,respondents drinking non-tap water,smoking respondents,respondents drinking alcohol,respondents never eating fresh vegetables or fruits,and respondents often eating pickled,sunned or hot foods(P<0.05).Results of logistic analysis showed that males,people aged 50～59 and 60～69,people drinking alcohol,people rarely eating fresh vegetables or fruits had an increased risk of upper gastrointestinal cancers and precancerous lesions.A total of 25 spatially heterogeneous high-incidence areas,36 low-incidence clusters and 50 non-significant distribution areas were identified(P<0.05).Conclusion:Residents aged 40～69 in the northeastern Sichuan exhibit a high incidence of up-per gastrointestinal cancers,particularly esophageal cancer,with significant spatial clustering.It is recommended to imple-ment targeted prevention and control measures for high-risk populations and areas to reduce disease burden.关键词
川东北地区/上消化道癌/危险因素/区域聚集Key words
Northeast Sichuan/Upper gastrointestinal cancer/Risk factors/Spatial clustering分类
医药卫生引用本文复制引用
王小棠,马艺丹,苟晓英,董娟,龙思泽,田小兵..川东北地区40～69岁居民上消化道癌危险因素及其区域聚集关系分析[J].肿瘤预防与治疗,2025,38(2):162-170,9.基金项目
This study was supported by grants from Nanchong Science and Technology Bureau(No.22YFZJZC0040). 南充市医卫领域自筹资金研发项目(编号:22YFZJZC0040) （No.22YFZJZC0040）
