神经病学与神经康复学杂志2024，Vol.20Issue(3)：77-84,8.DOI:10.12022/jnnr.2024-0073
血清NLRP3表达水平与阿尔茨海默病关系的Meta分析
The Meta analysis of the relationship between serum NLRP3 expression level and Alzheimer's disease
摘要
Abstract
Objective:To systematically review evaluate the association between the expression levels of NLR family,pyrin domain-containing 3 protein(NLRP3)in serum and Alzheimer's disease(AD). Methods:We searched databases including the Cochrane Library,PubMed,Embase,CBM,VIP,Wan Fang Data and CNKI databases committed to case control studies on the relationship between serum NLRP3 level and AD.The retrieval time limit was from the establishment of the database to August 2024.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies.Meta analysis was performed by Stata 15.1 SE and Review Manager 5.0 software. Results:Nine articles were included in total.The results of meta analysis showed that serum NLRP3 expression level was associated with AD(SMD=1.66,95％CI=1.28-2.04,P＜0.01).Subgroup analysis was conducted based on different NLRP3 measurement methods,and both the enzyme-linked immunosorbent assay group(SMD=1.48,95％CI=1.15-1.80,P＜0.01)and the PCR group(SMD=2.12,95％CI=0.78-3.45,P=0.002)showed an association between NLRP3 levels and AD.Sensitivity analysis showed that the results were stable. Conclusion:The meta analysis suggested that high level of serum NLRP3 expression may be associated with the development of AD.Limited by the quality and quantity of included studies,the above conclusions needed to be verified by more clinical studies.关键词
核苷酸结合结构域富含亮氨酸重复序列和含热蛋白结构域受体3/病例对照研究/Meta分析Key words
Alzheimer's disease/Nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3/Case control study/Meta analysis引用本文复制引用
张玲,冯蓓蕾,马莹,王长德..血清NLRP3表达水平与阿尔茨海默病关系的Meta分析[J].神经病学与神经康复学杂志,2024,20(3):77-84,8.基金项目
脑病多专业一体化诊疗模式平台建设[ZY(2018-2020)-FWTX-6013]Construction of a Multi disciplinary Integrated DiagnosisandTreatment Model Platform for Brain Disease[ZY(2018-2020)-FWTX-6013] （2018-2020）
