神经病学与神经康复学杂志2024，Vol.20Issue(3)：85-91,7.DOI:10.12022/jnnr.2024-0178
脑白质病变危险因素分析及其与脑卒中和痴呆的相关性研究
Analysis of risk factors for white matter lesion and its correlation with stroke and dementia
摘要
Abstract
Objective:To screen the risk factors of white matter lesion(WML)and explore the relationship between WML with stroke and dementia. Methods:In this study,a total of 260 patients with WML and 60 without WML underwent MRI were collected.The patients with WML were divided into 3 grades according to Fazekas scale.Gender,age,education level,hypertension,diabetes,hyperlipemia,hyperhomocysteinemia,overweight,smoking and drinking history,and stroke history of all enrolled patients were collected.Multiple ordered logistic regression analysis was used to identify the risk factors of WML.Compare whether the degree of WML in stroke patients is more severe than in non-stroke patients.MMSE scale was used to score the enrolled patients,analyzed the relationship between WML and cognition. Results:Age,history of hypertension,hyperhomocysteinemia and smoking were correlated with the severity of WML.The Fazekas classification of stroke patients was statistically different from that of non-stroke patients(Z=-10.305,P=0.000).With the increase of Fazekas grading,the MMSE score of patients decreased(rs=-0.511,P=0.000). Conclusion:Age,hypertension,hyperhomocysteinemia and smoking are independent risk factors for WML.WML may be a predictive signal of stroke.The more severe the degree of WML,the higher the risk of dementia in patients.关键词
脑白质病变/Fazekas分级/危险因素/脑卒中/痴呆Key words
White matter lesion/Fazekas grade/Risk factors/Stroke/Dementia引用本文复制引用
党翠娇,刘贵先,潘卫东..脑白质病变危险因素分析及其与脑卒中和痴呆的相关性研究[J].神经病学与神经康复学杂志,2024,20(3):85-91,7.基金项目
贵州省卫生健康委科学技术基金项目(gzwkj2021-027)Science and Technology Fund Project of Guizhou Provincial Health Commission(gzwkj2021-027) （gzwkj2021-027）
