神经病学与神经康复学杂志2024，Vol.20Issue(3)：98-107,10.DOI:10.12022/jnnr.2024-0159
外泌体在脑病中的作用机制及中药干预研究进展
Research progress on the mechanism of exosomes in encephalopathy and the intervention of Traditional Chinese Medicine
摘要
Abstract
Exosomes are smaller vesicles secreted by cells,enriched with cell-derived proteins,nucleic acids,lipids and other signaling substances,which have physiological functions such as removing waste materials,mediating intercellular information transfer and generating immune tolerance.Traditional Chinese Medicine(TCM)and its main active ingredients can be used to treat cerebral diseases by regulating exosomes,but the mechanism of action is still unclear.In this paper,we reviewed the characteristics of exosomes in cerebral diseases(ischemic stroke,cerebral hemorrhage,vascular dementia,Alzheimer's disease,multiple sclerosis)and the mechanism of action of the main active ingredients of traditional Chinese medicines on exosomal proteins,so as to provide a new strategy and a new way of thinking for the treatment of cerebral diseases.关键词
外泌体/脑病/中药/作用机制/研究进展Key words
Exosomes/Encephalopathy/Traditional Chinese Medicine/Mechanism/Research progress引用本文复制引用
邓益,汪麟双,孙晨格,陈欣怡,彭文茜,卫东锋..外泌体在脑病中的作用机制及中药干预研究进展[J].神经病学与神经康复学杂志,2024,20(3):98-107,10.基金项目
国家自然科学基金面上项目(82174210) （82174210）
中国中医科学院第14批自主选题项目(ZZ14-FL-005) （ZZ14-FL-005）
中国中医科学院科技创新工程重大攻关项目(CI2021A01306)National Natural Science Foundation of China General Program(82174210) （CI2021A01306）
The 14th Batch of Self-selected Project of China Academy of Chinese Medical Sciences(ZZ14-FL-005) （ZZ14-FL-005）
Major Key Project of Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(CI2021A01306) （CI2021A01306）
