神经病学与神经康复学杂志2024，Vol.20Issue(4)：125-133,9.DOI:10.12022/jnnr.2024-0062
阿尔茨海默病中Aβ在神经元与体内的代谢研究
The metabolism of amyloid-β in neurons and in vivo in Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by memory impairment,cognitive decline and neuronal loss.Its pathogenesis involves a variety of factors,among which amyloid-β(Aβ)is critical in neurons and the body.Aβ is the decomposition product of human amyloid precursor protein(APP)through various amyloid processing routes and non-amyloid processing routes,and is cleared through various ways such as cerebrospinal fluid and inter-tissue fluid lymphatic drainage,cell clearance,blood and brain barrier transport and enzymatic hydrolysis.The generation and clearance of Aβ is a dynamic and balanced process,and the imbalance of its balance will accumulate Aβ in the brain,leading to neuronal cell death,impaired synaptic function and neuronal network changes,inducing and exacerbate AD symptoms.This review expounded the mechanisms of Aβ generation,clearance and metabolism in AD,summarized the interaction mechanisms of Aβ with neurons,astrocytes,urea cycle,etc,and provided new ideas for further discovery of new therapeutic and diagnostic targets for AD.关键词
阿尔茨海默病/β-淀粉样蛋白/人类淀粉样前体蛋白/血脑屏障/星形胶质细胞/尿素循环Key words
Alzheimer's disease/Amyloid-β/Amyloid precursor protein/Bloodbrain barrier/Astrocyte/Urea cycle引用本文复制引用
荆玮,张海涵,单悦童,刘逸舟,王宇泽,潘卫东..阿尔茨海默病中Aβ在神经元与体内的代谢研究[J].神经病学与神经康复学杂志,2024,20(4):125-133,9.基金项目
上海市浦东新区卫健委行业专项(PW2022E-03)Industry Special Project of Shanghai Pudong New Area Health Commission(PW2022E-03) （PW2022E-03）
